Effect of Momordica Charantia juice on blood glucose levels in healthy and diabetic rats
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Background and Objectives: Pharmacotherapeutic interventions in diabetes are expensive and also associated with adverse effects therefore the need for alternate treatment modalities. Momordica Charantia(MC) is commonly used as food and medicine by both diabetic and healthy people. MC is widely being used in healthy people, in whom its glycaemic effects are unknown. The present study therefore aimed to investigate the blood glucose lowering effect of MC in both healthy and diabetic subjects using laboratory animal model and its potency was compared with a standard antidiabetic drug like pioglitazone. Methodology: Albino rats were divided into 5 groups; Group 1(normal controls), Group 2(normal controls fed with bitter melon juice) Group 3(diabetic controls), Group 4(diabetic rats treated with pioglitazone) and Group 5(diabetic rats treated with bitter melon juice (BMJ). Type 1 Diabetes was induced by intraperitoneal injection of streptozotocin to group 3, 4 and 5. Blood glucose levels were estimated on day 0, 7, 14 21 and 28 days. Fasting blood glucose was estimated by glucose oxidase assay. Results were analyzed by repeated measure ANOVA test. Result: There was significant reduction in blood glucose levels in group 2 rats when compared to normal controls. BMJ significantly reduced blood glucose levels in group 5 as compared to pioglitazone group (p=0.05).Conclusion: Blood glucose level in both group 1 and 2 remained within the normal range thus emphasising the role of BMJ in modulating the blood glucose. BMJ consumed over a period of time may prove useful in prevention and treatment of diabetes.
Authors and Affiliations
Swetha Chandru, Prashant Vishwanath, Akila Prashant, Devananda Devegowda, Suma M N
Keywords
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