Serum glycoproteins in patients with severe depression compared with normal subjects
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 3
Abstract
Background: Depressive illness is considered to be a psychoneuro-immunological disorder due to peripheral immune activation through the release of proinflammatory cytokines. Cytokines enhance the hepatic synthesis of glycoproteins. Several studies have shown alpha-1acid glycoprotein levels are elevated in patients with major depressive disorder. Aim: To investigate the changes in the level of serum glycoproteins in patients with severe depression and compared with normal subjects. Material and Methods: The present study conducted on 100 subjects which were grouped as cases (n=50) and controls (n=50). The patients who were diagnosed as having severe depression by the clinical psychiatrist were included in the cases group. Protein bound hexose (PBH) was estimated by the method of Weimer HE and Moshin JR and Protein bound hexosamine (PBHex) was estimated by the method of Winzler. Results: The mean of PBH levels in severe depression cases was 191.05±4.01 mg% and in controls was 102.50±5.81 mg% (p<0.0001). Whereas, the mean PBHex level in cases and controls was 97.50±5.06 mg% and 78.50 ± 4.97 mg% (p<0.0001). Conclusion: The present study shows significantly increased levels of serum glycoproteins in severe depressive patients. As serum glycoproteins are non-specific indicators of severe depression, they cannot be used as a diagnostic marker. At best these levels may be used to study the response to treatment.
Authors and Affiliations
N Dheebalakshmi, B Poonguzhali
Keywords
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