Serum glycoproteins in patients with severe depression compared with normal subjects
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 3
Abstract
Background: Depressive illness is considered to be a psychoneuro-immunological disorder due to peripheral immune activation through the release of proinflammatory cytokines. Cytokines enhance the hepatic synthesis of glycoproteins. Several studies have shown alpha-1acid glycoprotein levels are elevated in patients with major depressive disorder. Aim: To investigate the changes in the level of serum glycoproteins in patients with severe depression and compared with normal subjects. Material and Methods: The present study conducted on 100 subjects which were grouped as cases (n=50) and controls (n=50). The patients who were diagnosed as having severe depression by the clinical psychiatrist were included in the cases group. Protein bound hexose (PBH) was estimated by the method of Weimer HE and Moshin JR and Protein bound hexosamine (PBHex) was estimated by the method of Winzler. Results: The mean of PBH levels in severe depression cases was 191.05±4.01 mg% and in controls was 102.50±5.81 mg% (p<0.0001). Whereas, the mean PBHex level in cases and controls was 97.50±5.06 mg% and 78.50 ± 4.97 mg% (p<0.0001). Conclusion: The present study shows significantly increased levels of serum glycoproteins in severe depressive patients. As serum glycoproteins are non-specific indicators of severe depression, they cannot be used as a diagnostic marker. At best these levels may be used to study the response to treatment.
Authors and Affiliations
N Dheebalakshmi, B Poonguzhali
Keywords
Related Articles
- EP ID EP410307
- DOI -
- Views 181
- Downloads 0
Study of the levels of lipid profile and MDA levels and their correlation in hypertensive chronic smokers
Background: Atherosclerosis is the underlying process involved in coronary heart disease, peripheral vascular disease and stroke. Elevated plasma low-density lipoprotein cholesterol levels, lowered high-density lipoprote...
A comparative study of serum sodium and potassium levels between pre-eclamptic patients and normal pregnant women
Background: Hypertensive disorders in pregnancy are one of the major causes of maternal and perinatal mortality and morbidity. Though various factors like placental ischemia, immunological maladaptations, genetics and su...
Evaluation of thyroid function in patients of chronic kidney disease
Background: Chronic Kidney Disease (CKD) is abnormal kidney function with low GFR (<60 ml/min/1.73m2) for 3 or more months. Prevalence of CKD in India is 17.2% and over 2 million people world wide receive dialysis treatm...
Serum adenosine deaminase levels in patients with type 2 diabetes mellitus and its relation with fasting blood glucose and glycated hemoglobin levels
Background: Insulin resistance and decreased insulin secretion are the main physiological abnormalities of Type 2 Diabetes Mellitus (DM). Cell mediated immune system disturbance and improper T lymphocyte function also co...
Correlation of Thyroid Hormones with Vitamin D Status in Acutely Ill Children
Objective: The aim of the study is to correlate thyroid function tests with vitamin D status and the existence of “Euthyroid Sick Syndrome (ESS)”, in acutely ill children. Methods: The present case-control study was cond...