Effect of tobacco smoking on P300 event related potential in new beginners and chronic smokers
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 6, Issue 3
Abstract
Background: Identification of effect of smoking on P300 Event related potential which in turn represents basic characteristics of neurocognitive functioning which may help to elucidate the mechanism of tobacco dependence. Objectives: To study and compare effect of smoking on auditory P300 Event related potential in chronic smokers (Group I) and new beginners of smoking (Group II) before and immediately after cigarette smoking. Materials and Methods: Auditory P300 amplitude and latency were recorded in 50 Group I and 50 Group II male individuals in age group of 25 to 35 years before and immediately after smoking. 30 age and sex matched non smokers were taken as controls. Results: Group I had P300 of significantly lower amplitude and longer latency (p<0.001) compared to Group II and controls before smoking. Significantly reduced latency and increased amplitude of P300 (p< 0.001) was noticed in Group II immediately after smoking compared to Group I. In group I after smoking though increase in amplitude (p< 0.01) and reduced latency (p< 0.05) was noticed, still overall P300 was reduced in chronic smokers before or after smoking. Conclusion: Improvement in cognitive function though occurs immediately after cigarette smoking there occurs progressive decline in cognitive function with years of Chronic smoking. Reduced P300 may be a marker of risk fornicotine dependence.
Authors and Affiliations
Sunitha M, S V Brid, Suresh Y Bondade S
Keywords
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