Effects of Fentanyl and Butorphanol on Induction Dose of Propofol in Adults
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: Propofol induction dose is reduced with concomitant use of opioids as a result of a possible synergistic action. Objective: To study the effects of fentanyl and butorphanol on induction dose of propofol in adults. Methods:Onetwentypatients of either sex, of ASA(American society of anesthesiologist) I and II, undergoing elective surgery under general anaesthesia was taken and randomly allocated into three groups of 40 each. Group I received intravenous fentanyl 2μg/kg, Group II 20μg/kg and Group III 40μg/kg butorphanol. Induction of anaesthesia was done with propofol (30mg/10s) till the loss of response to verbal commands. Patients hemodynamic were recorded before administration of study drugs, 5 minutes thereafter, at the time of induction, for 2 min post-induction and post-intubation for 5 min at 1 min interval. The study concluded 5 min after intubation. Results: Fentanyl 2μg/kg reduces the induction dose of propofol to 1.01±0.25 mg/kg.Butorphanol20μg/kg reduces the induction dose of propofol to 0.95±0.18 mg/kg and butorphanol 40 μg/kg to 0.90±0.15 mg/kg. However, sedation was observed to a greater degree with butorphanol 40 μg/kg. Conclusion:Fentanyl 2μg/kg, butorphanol20μg/kg and 40μg/kg reduces the induction dose of propofol comparably.However butorphanol 40 μg/kg was associated with more sedation.
Authors and Affiliations
Dr. Haobam Sofia, Dr. Maharabam Binarani, Dr. L Deban, Dr. H. Kenedy, Dr. Aditi Bhatacharya, Dr. Y. Arunkumar
Keywords
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- EP ID EP595126
- DOI 10.9790/0853-1604084853.
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