ЭФФЕКТИВНОСТЬ МОНТЕЛУКАСТА В УСЛОВИЯХ ПЕРСИСТЕНЦИИ АТОПИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ
Journal Title: World Science - Year 2018, Vol 6, Issue 6
Abstract
Aim. To evaluate the montelukast`s effect on level of forced expiratory volume on first second (FEV1) and serum immunoglobulin E (Ig E) in women with persistent atopic asthma. Materials and methods. 95 patients with persistent atopic asthma were observed. They were divided into 2 groups: main group – 60 patients who received montelukast (10 mg, orally), as add-on therapy to inhaled corticosteroids (ICS) and bronchodilators, and compared group 35 patients who received only ICS and bronchodilators. Level of Ig E was assayed with electrochemiluminescence immunoassay analyzer in addition to general examination and spirometry. Results. It was not observed significant difference in Ig E level in both groups. In the main group level of Ig E was 306,5±17,98 IU/ml, while in the compared group – 301,1±26,16 IU/ml. By the end of the study there was a statistically significant decrease of Ig E level only in the main group - 128,6±8,54 IU/ml (p<0,001). The indicators of the FEV1 at main and compared groups after treatment significantly increased (p<0,05), also there was statistically difference (p<0,05) between main (FEV1 – 82,2±0,18 %) and compared (FEV1 – 87,3±0,32 %) groups. The data indicated a correlation between level of serum Ig E and FEV1. Conclusions. Montelukast improves clinical, functional manifestations of persistent atopic asthma in women and increases anti-inflammatory effects.
Authors and Affiliations
О. А. Штепа, И. П. Гармиш, С. В. Маргитич, Л. В. Моисеева, Д. М. Максаков
Keywords
Related Articles
- EP ID EP332398
- DOI 10.31435/rsglobal_ws/12062018/5861
- Views 103
- Downloads 0
ІСТОРИЧНІ АСПЕКТИ НАУКОВОГО ВИВЧЕННЯ КУЛЬТУРИ СОЇ В КРАЇНАХ АЗІЇ ТА ЄВРОПИ З НАЙДАВНІШИХ ЧАСІВ ДО ПОЧАТКУ ХХ СТ.
The issues of the formation of soy cultivation as an independent branch of world agriculture in the scientific literature have practically not been covered. Separate historical and socio-economic aspects of the origin of...
К ПРОБЛЕМЕ ВНЕДРЕНИЯ ИННОВАЦИОННЫХ ОБРАЗОВАТЕЛЬНЫХ СТРАТЕГИЙ В ПРОЦЕСС ОБУЧЕНИЯ СТУДЕНТОВ ИНЖЕНЕРНЫХ СПЕЦИАЛЬНОСТЕЙ
In the article the problem of introduction of innovations in training of students of engineering specialties is investigated. Attention is focused on the growing trend towards the use of innovative technologies that allo...
STYLISTIC FUNCTIONS OF BIBLICAL ALLUSIONS IN THE LITERARY TEXTS
The article presents a brief overview of the research devoted to biblical allusions (BA-s) functioning in literary texts. It describes the process of realization of biblical allusion in speech, defines the essence of sty...
КОНФЛИКТ – ЭТО КОНФЛИКТНАЯ СИТУАЦИЯ ПЛЮС ИНЦИДЕНТ
Столкновение, конфликт происходит только тогда, когда существующие противоречия, разногласия нарушают нормальное взаимодействие людей и препятствуют достижению поставленных целей. В процессе конфликтного взаимодействия е...
ОСОБЛИВОСТІ ПРОЦЕСУ ГУМАНІЗАЦІЇ ВИКЛАДАННЯ АНГЛІЙСЬКОЇ МОВИ У СЛОВАЦЬКІЙ РЕСПУБЛІЦІ
The article analyzes the need to humanize education in the Slovak Republic, namely to look for more effective ways of teaching English as a foreign language. Traditional teaching still dominant in many secondary schools...