Efficacy of cell block immunocytochemistry in the diagnostic workup of non hodgkin lymphoma-experience from a tertiary care hospital in North India
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 2
Abstract
The WHO 2016 update on lymphoid neoplasms incorporates criteria independent of tissue architecture in the diagnosis and subclassification of nonHodgkin lymphoma Thus lymphoid neoplasms with characteristic immunophenotypes andor cytomorphology could be classified with FNA material with appropriate use of ancillary methods We analysed the efficacy of cytomorphology and cell block immunocytochemistry CBICC in in diagnostic workup of nonHodgkin lymphoma diagnosis on FNA material 65 clinically suspected cases of lymphoma presenting with lymphnode enlargements were analysed FNAC and CBICC were performed and compared with the subsequent biopsy The sensitivity specificity PPV and NPV of CBICC in the diagnosis of NHL were 846 75 956 and 428 respectively in our studyWe also observed that use of CBICC can have significant logistic implications in patient management in terms of reducing the turnaround time to diagnosis and improving the accuracy in diagnosis on FNAC ICC on cell blocks can easily be done on FNA material and is a very useful adjunct to FNAC in establishing the diagnosis in a suspected case of NHL especially when a biopsy is not availableKeywords Cell block immunocytochemistry NHL FNAC Ancillary methods
Authors and Affiliations
Pradyumn Singh, Anurag Gupta, Namrata P Awasthi, Ashish Singhal, Gaurav Gupta
Keywords
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- EP ID EP475490
- DOI 10.18231/2394-6792.2018.0041
- Views 39
- Downloads 0
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