Evaluation of Anti Diabetic Activity (In-vitro) of Psidium guajava Unripe Fruits Aqueous Extract
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 3
Abstract
Abstract: Diabetes Mellitus is a major endocrine disorder caused by the failure of the body function properly carbohydrate metabolism as well as changes in lipid and protein metabolism, thus contributing to hyperglycemia (increased blood sugar levels above normal), glycosuria (the presence of sugar in the urine), polyuria (the need to urinate frequently), polydipsia (always thirsty) and polyphagia (increase appetite). Numerous herbal plants and their formulations are therefore used widely for the various forms of diseases. One well-known herb of this kind is Psidium guajava Linn (Family: Myrtaceae) is a semi deciduous tropical tree commonly known as guava or ‘Amrood’ in north India and is widely grown throughout India. The present study was undertaken to evaluate the Anti diabetic activity (In-vitro) of Psidium guajava unripe fruit aqueous extact. The Evaluation of anti-diabetic activity of extract by In-vitro method by glucose uptake by yeast cells the rate of uptake of glucose into the yeast cells was linear in all the 3 glucose concentrations. The extract of Psidium guajava exhibited significantly activity than the control. However, the percent increase in the glucose uptake by the yeast cells was observed to be inversely proportional to the glucose concentration and was found to decrease with increase in the molar concentration of the glucose solution. The effect of the plant extracts on retarding glucose diffusion across the dialysis membrane is shown in Table 3. The rate of glucose diffusion was found to increase with time from 1 hour to 5 Hours In the present study, the movement of glucose across the Biological membrane was monitored once in 1 Hour till 5 Hours and it was found that, both the samples of plant extracts and Standard Acarbose was demonstrated significant inhibitory effects on movement of glucose into external solution across the biological membrane compared to control.
Authors and Affiliations
A. Narayana Rao, Donthu Susmitha, Gurajala Lalitha, Mandhalapu Sesha Pavani, Shaik Yakoob, Velpula Sai Tejaswini, Tanuku Satyanarayana
Keywords
Related Articles
- EP ID EP480150
- DOI -
- Views 119
- Downloads 0
Bioenhancers from Mother Nature: A Paradigm for Modern Medicines
Pharmaceutical corporations round the globe have continually been within the urge of discovering innovative blockbuster medicine for numerous ailments by outlay billions of bucks for the drug discovery programmes. With t...
Antioxidant and Anti-Inflammatory Activity of Proteins Isolated From ZingiberOfficinaleRoot
To investigate the in vitro, antioxidant and anti-inflammatory activity of the proteins isolated fromZingiberofficinale, proteins isolated by Ammonium sulphate precipitation method. In vitro antioxidant studies were carr...
Study of Effect of Dexmedetomidineand Clonidine as Adjuvant with Bupivacaine on the onset & Duration of Analgesia and Anaesthesiain Supraclavicular Brachial Plexus Block
Many adjuvants have been used with local anaesthetics to reduce the time of onset and prolong the duration of analgesia in brachial plexus blocks.Very few studies are there comparing dexmedetomidine versus clonidine as a...
Changes in the Amounts of Amoxicillin and Metronidazole Used for Helicobacter pylori Eradication Therapy in the Stomach after Their Oral Administration to Rats
In the eradication therapy of Helicobacter pylori, the changes of the amounts and concentrations of antibiotics in the stomach after oral administration were unclear. Amoxicillin (AMX) and metronidazole (MTZ), which are...
Study on Prevalence of Anaemia among School Children in a Rural Community Setup
Anaemia is one of the important public health problem, which affects the world’s population widely. Among all types of anaemia, iron deficiency anaemia is commonly seen in people of developing countries. The prevalence...