Evaluation of antipyretic efficacy of a traditional herbal medicine.
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 11
Abstract
The aim of the present study was to carry out phytochemical and pharmacognostical screening, efficacy and safety studies on one of the traditionally used Ayurvedic Polyherbal drug (Drug-PD). This compound is described by Charak and is specifically composed of stems of Guduchi, fruits of Amlaki and rhizomes of Mustak. The test drug is coded as ‘PD’ for the purpose of this study. Different extracts were prepared out of PD and bioactivity was observed in the acetone extract. This part was investigated in detail for antipyretic and related activity in rodents. The acetone extract of Drug PD was investigated for its antipyretic activity in rats and acute oral toxicity was determined in mice. Physical and pharmacognostical parameterization of the crude drug is reported as a quality marker. A test for phytoconstituents in bioactive extract indicated presence of flavonoids, tannins, and carbohydrates. The extract was found to show significant antipyretic activity at 400mg/kg and 600mg/kg body weight and the response was dose dependent. The acute toxicity study indicated no toxic effect up to a dose of 1000mg/kg in mice. Systematic observations are suggestive of quality standardization of a traditional antipyretic preparation in practice. The work also reports a maximum antipyretic efficacy being retained at the dose of 600mg/kg of the research drug. Additionally, the test drug is safe for a further advanced formulation development work out of the traditional knowledge.
Authors and Affiliations
Sohini Majumdar, Saumyakanti Sasmal, Arup Mukherjee, *Mradu Gupta
Keywords
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