Evaluation of cardioprotective activity of maceration extract of Elettaria cardamomum in doxorubicin induced cardiotoxicity in rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 5, Issue 6
Abstract
The plant of Elletteria cardamom was collected and phytochemical studies were made with different solvents using ethanol and water. The extracts showed different extractive values (2.0 and 9.0 respectively) and showed the presences of different bioactive compounds like Alkaloids, Saponins, flavonoids, Terpenes, Glycosides steroids. Based upon the literature this given us the positive signal which may induce cardio protective activity. Treatment with Ellettaria cardamom extract high dose 500mg/kg.b.w lowers the LDH levels, SGOT levels, SGPT levels, Total protein levels, Serum albumin levels, Alkaline phasphatase levels and Triglycerides in doxorubicin induced cardiac rats. Treatment with low dose 100mg/kg.b.w of Elletteria cardamom extract lowers the Triglycerides levels in doxorubicin cardiac rats. Treatment with high dose 500mg/kg.b.w of Elletteria cardamom extract lowers the total cholesterol levels in doxorubicin cardiac rats. Treatment with high dose 500mg/kg.b.w of Elletteria cardamom extract improves the HDL Cholesterol levels in doxorubicin cardiac rats. Treatment with high dose 500mg/kg.b.w of Elletteria cardamom extract lowers the LDL Cholesterol levels in doxorubicin cardiac rats. Treatment with high dose 500mg/kg.b.w of Elletteria cardamom extract lowers the VLDL Cholesterol levels in doxorubicin cardiac rats. Treatment with Elletteria cardamom extract high dose 500mg/kg.b.w lowers the total chloride levels in doxorubicin induced cardiac rats.
Authors and Affiliations
Mohammed Shahidullah, M. Janarthan, Md Salman Khan
Keywords
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