Evaluation of Histopathological Effects of Contaminated Unexpired Gentamicin Injections on the Kidney Tissues of Juvenile Wistar Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
The histo-pathological effects of contaminated gentamicin injections on the kidney tissues of juvenile wistar rats have been investigated using standard microbiological and histo-pathological techniques. Freeze-dried and heat fixed thin sections of wistar rats’ kidney were observed under the microscope using x10, x40 and x100 magnifications. The results revealed marked necrosis and erosion of proximal borders especially the focal epithelium of proximal convoluted tubules (PCT) of the kidney, with the retention of the cytoarchitecture. Plasmolysis was observed in the epithelial cells of the distal convoluted tubules (DCT) when treated with contaminated unexpired gentamicin injection sample as compared with control. Glomerular hypoplasia and fibrosis of the Bowman’s space occurred in the kidney when compared with the control. Also medulla interstitial oedema leading to focal tubular fibrosis as a result of microbial activity was observed when compared with control. Interstitial hemorrhage which led to complete tubular necrosis with loss of defined tubular cyto-architecture was observed. This effect made the tissue fibrous, resulting in a nonfunctional or shrunken kidney as compared to control. Results obtained from this work have raised serious health concerns, considering the risk posed by contaminated drugs on patients.
Authors and Affiliations
Iquo Asu Takon
Keywords
Related Articles
- EP ID EP519502
- DOI -
- Views 85
- Downloads 0
Effect of the Pyridoxine Supplements on the Minimum Inhibitory Concentration of the Co-Ampicillin-Cloxacillin against Staphylococcus Aureus: In Vitro Study
Background: Pyridoxine or vitamin B6is a water-soluble vitamin that is naturally present in many foods, added to others, and available as a dietary supplement. Microorganisms synthesized pyridoxine and played a role in t...
Seroprevalence of Transfusion Transmitted Infection (TTI) among Healthy Blood Donor and Their Distribution within Blood Groups - A Study from Kolkata
Introduction: Blood transfusion is an integral and life saving procedure of modern medicine, but simultaneously it carries the risk of transmitting the life- threatening transfusion-transmissible infectious agents such a...
Effects of Swimming Combined Training on Lipid Profiles in Male Adolescent Swimmers
Background: The present study was carried out with a view to investigate the effects of swimming combined training on lipid profiles in male adolescent swimmers. Methods & Materials: The study followed a pre test and pos...
Prospective Randomized Study on the Effectiveness of Oral Antibiotic Prophylaxis in Preventing Surgical Site Infection in Elective Colorectal Surgery
Background: Surgeries of the colon and rectum are categorized as clean-contaminated procedures. Increased incidence of surgical site infections associated with these procedures make antibiotic prophylaxis and bowel prepa...
In Vitro Study Comparing the Efficacy of Radiograph and Apex Locator in Determining Working Length in Human Maxillary Molars
The objective of this invitro study was to find out if a buccal curve in the palatal roots of maxillary molars affected the clinician’s ability to accurately determine working length. 30 extracted intact human maxillary...