Evaluation of Toxic Effect of Terminalia Chebula Fruit Extract in Albino Rats
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 4
Abstract
The present study aims to analyse the phytochemicals and test the toxic effect of the fruit extract of Terminalia chebula using three different solvents viz ethanol, acetone and benzene by examine the changes in behaviour, body weight, food intake, water intake, haematological parameters (WBC total count, WBC differential count, RBC, Hb, HCT, MCV, MCH, MCHC and platelet count) and histological changes in the vital organs such as lungs, heart, liver and kidney. No behavioural changes or any toxic symptoms and mortality was observed throughout the experimental period. There is a slight increase or decrease in the body weight of the extract treated groups compared to control group rats. The food intake and water intake of the control and extract treated rats showed slight variations but not showed the abnormal intake of food and water throughout the experimental period. The haematological parameters showed significant difference among the different extract treated rats and control rats, but the levels are not exceeded from the normal range. The microscopic and macroscopic examination of the vital organs such as lungs, heart, liver and kidney showed normal cell structures, blood vessels and nuclei. Thus the present study revealed that the ethanol, acetone and benzene extracts of Terminalia chebula fruit did not produce any toxic effects at the high dose of 2000mg/kg body weight and is found to be safe. Thus it is concluded that the plant extract of Terminalia chebula fruit upto 2000 mg/kg body weight was used for further evaluation studies.
Authors and Affiliations
Elavarasi, S. , Horne Iona Averal Nevika E, P. Kanimozhi
Keywords
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