Abstract

Objective: ‘Basinga’ is traditionally used as wound healing plant in Uttarakhand, India and this study was design to evaluate the wound healing potential of Ageratina adenophora for establishment of its traditional claim as wound healer. Experimental Approach: Wound healing potential of Ageratina adenophora ethanolic extract was estimated by excision and incision wound models. The ethanolic extract was formulated as gel and applied on excision and incision wounds in thirteen day study. After treatment, wound area and epithelialization time was estimated in excision and tensile strength in incision wounds. Wound index was recorded in both excision and incision wounds. Findings: The estimated wound area was used to calculate to percentage wound contraction. Ethanolic extract of Ageratina adenophora gel and standard Aloe vera gel showed highly significant activity when compared with pure gel control. The tensile strength, epithelialization time and wound index data showed that plant possess moderately significant wound healing potential in both excision as well as incision wounds. Discussion: The plant Ageratina adenophora showed strongly significant (p<0.01) wound healing potential in excision as 90.98% wound contraction and 36.16 % reduction in epithelialization time while in incision model, the plant extract showed significant increase (37.86%) in tensile strength on 13th day when compared to pure gel control. Wound index data clearly showed that quality of healing was much better in plant extract as well as Aloe vera treated animals as compared to pure gel control. Conclusion: The present study was showed that ethanolic extract of Ageratina adenophora possess strongly significant wound healing potential as standard Aloe vera which provide an experimental support to traditional claim as wound healer for this plant.

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