Evalution of anti urolithiatic activity of aqueous extract of stem core of Musa paradisiaca againest ethylene glycol and ammonium chloride induced urolithiasis on wistar rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
The anti-urolithiatic activity of the Aqueous extract of the stem core of Musa paradisiaca (family: musaceae) was investigated on Ethylene glycol and ammonium chloride induced on albino rats. A comparison was made between both plant extract and a known anti urolithiatic drug cystone (5mg/kg-1). The dried powder ofstemcore of Musa paradisiaca was subjected to extraction by continuous hot extraction method using Distilled water as a solvent. Phytochemical estimation was done for the presence of phytoconstituents. Dose selection was made on the basis of acute oral toxicity study (200mg/kg-1, 400mg/kg-1 bodyweight) as per OECD guidelines. Oral administration of extract of Musa paradisiaca for 28days resulted in significant reduction in urine level. Ethylene glycol and Ammonium chloride induced lithiatic rat model and oral urine tolerance test (OUTT) model was used for evaluation of anti lithiatic activity. The biochemical parameters were analysed. All rats in the lithiatic groups had urine and serum levels well within the lithiatic range, at the initial stage of the experiment but after four weeks of treatment with extracts or cystone the urine, serum significantly dropped in dose-dependent manner. The results suggest that the aqueous extracts of the Stem core of Musa paradisiaca restored the metabolic changes in Ethylene glycol and ammonium chloride lithiatic rats.
Authors and Affiliations
Thirumala K, Janarthan M, Firasat Ali M
Keywords
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