EVIDENCE OF GENETIC INSTABILITIES AMONG WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND INFERTILITY
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 11
Abstract
PCOS is one of the most common endocrinopathies. It occurs in 4-8% of women during their reproductive years. Infertility in PCOS patients was related to the effect of follicular fluid's oxidative stress levels on the meiotic spindle formation in the oocyte. The PCOS is a familial disorder, but the genetic basis of the syndrome remains controversial. Hence aim of the study was to evaluate the evidence of genetic instabilites among women with PCOS and infertility. The present study includes 45 study subjects and 25 healthy control subjects. The extent of somatic DNA damage was quantified by Cytokinesis-Block Micronuclei (CBMN) assay. Detailed demographic, clinical and lifestyle characteristics were compared with subjects. The micronuclei frequency was significantly elevated in study subjects than the control subjects. Various risk factors such as demographic, biochemical and lifestyle characters were showed increased micronuclei frequency which leads to infertility. Lifestyle modification is very important in the treatment for PCOS, as weight loss and exercise have been shown to lead to improved fertility and lowering of androgen levels. The high incidence of genetic instabilities in subjects with PCOS and infertility clearly warrants periodical examinations and counseling.
Authors and Affiliations
Suji Sundar LS, PS Vidya, Dinesh Roy D
Keywords
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