Expression of transcription nuclear factor NFκB in laryngeal carcinoma tumor cells – correlation with IL-10 expression by blood mononuclear cells and clinicomorphological features
Journal Title: Otolaryngologia Polska - Year 2009, Vol 63, Issue 7
Abstract
Purpose: Transcription nuclear factor NFκB (p65-p50/RelA) is an activator of transcription process and regulates the apoptosis, cell cycle, proliferation, secretion of cytokines, angiogenic and growth factors by initiation gene transcription. NFκB can be activated by signaling pathway following IL-10 stimulation. The aim of this study was to estimate NFκB cytoplasmic and nuclear immunoexpression and to analyze the connection with clinicopathological features and IL-10 concentration produced by blood mononuclear cells in patients with laryngeal carcinoma. Materials and methods: Analysis of NFκB expression by immunmohistochemistry and IL-10 production by PBMCs and measured by Elisa in 45 patients with squamous cell carcinoma of the larynx were performed. Connections NFκB immunoexpression with clinicomorphological features (pT, pN, Anneroth, Batsakis i Lunas’ classifi cation) and IL-10 secretion were analyzed. Results: Authors reported statistical correlation between NFκB cytoplasmic level and clinicomorphological parameters such as neoplasm advance according to Anneroth, Batsakis i Lunas’ classifi cation and depth of invasion as well as IL-10 secretion by PBMCs. Conclusion: Our studied indicated the important influence of NFκB activity on advance in laryngeal carcinoma as well as connection of anti-infl ammatory and regulatory cytokine IL-10 produced by immunocompetent cells for course of neoplasm disease.
Authors and Affiliations
Katarzyna Starska, Olga Stasikowska, Iwona Lewy-Trenda, Ewa Głowacka, Marek Łukomski
Keywords
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