FAILING OF INFORMATION TRANSMISSION BY DORSAL HIPPOCAMPUS DUE TO MICROINJECTION OF COLCHICINE IN RAT’S CORTICAL AREA 1
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjective: Colchicine has been introduced recently as a neurotoxin with damage effect on neurons of hippocampal cortical area 1 (CA1). Effect ofcolchicine, a plant derived neurotoxin on memory retrieval was explored experimentally by means of novelty seeking task in intact Wistar rats.Methods: The subjects were cannulated by stereotaxic apparatus at coordinates adjusted for the CA1 area. After recovery, all animals experiencedthe novelty seeking paradigm using an unbiased conditioning device. First, they were habituated with the conditioned place preference (CPP)apparatus. They were then confined in one part of the CPP box for 3 consecutive days. Finally, the animals were microinjected colchicine (1-25 μg/rat)intra‑hippocampal CA1 prior to testing. Control group was cannulated too, but, solely injected saline (1-μl/rat, intra-CA1). The time spent in the novelpart of the device and the motivational signs of the rats were measured. Furthermore, the possible cell injury effect of the toxin on the CA1 layer wasverified.Results: The alkaloid caused significant novelty seeking behavior in the experimental animals though did not show a significant effect on thecompartment entering. The destruction effect of the neurotoxin on the treated rats’ dendrites spines was evidenced.Conclusion: Based on this finding the information transmission by dorsal hippocampal pyramidal cells may impair with an administration ofneurotoxin colchicine, intra-CA1.Keywords: Colchicine, Memory retrieval, Novelty seeking behavior, Cortical area 1, Pyramidal cell layer.
Authors and Affiliations
Manizheh Karami, Afsaneh Afsaneh Naseri, Mohammadreza Jalali Nadoushan
Keywords
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