Favorable Effect of Bromocriptine and Pentoxifylline in Mild Graves Disease Orbitopathy: A Randomized, Open, Clinical Trial
Journal Title: Journal of Endocrinology and Diabetes - Year 2017, Vol 4, Issue 2
Abstract
Background:Graves’ orbitopathy (GO) is the most frequent extra thyroidal manifestation of Graves’ disease. Treatment for mild cases consists in euthyroidism restoration and topical treatments. Aim: To evaluate the effect of bromocriptine (BRC) or pentoxifylline (PTX) added to methimazole (MTZ) in proptosis, clinical activity, and quality of life in individuals with mild GO. Methods: Randomized, open, clinical trial. Forty-five patients with mild GO with an onset of less than one year were randomly assigned to MTZ, MTZ+BRC, or MTZ+PTX treatment during one year. Proptosis was measured with exophthalmometry, clinical activity was evaluated using the Clinical Activity Score (CAS), and the Graves’ Orbitopathy Quality Of Life (GO-QOL) questionnaire was also applied. Results: Thirty-five patients were analyzed, 13 assigned to MTZ, 9 to MTZ+BRC, and 13 to MTZ+PTX. After one year, a decrease in proptosis was documented in the MTZ+BRC group. Proptosis on right eye (OD) decreased from 20 [18-21] to 18 [16-18] mm (p= 0.006), and on left eye (OS) from 20 [19-20] to 18 [16-18] (p= 0.006). MTZ+PTX treatment also decreased proptosis. In OD from 19 [17.5-19] to 16.5 mm [16-19] (p= 0.120) and in OS from 19 [17.5-19] to 17 [16-20] (p= 0.025). No change was observed on the MTZ group. The CAS and GO-QOL scores significantly improved in all groups. Conclusions: BRC or PTX treatments added to MTZ improved proptosis in individuals with recent onset, mild GO. CAS and quality of life similarly improved in all groups.
Authors and Affiliations
Francisco Cárdenas Velázquez, Paloma Almeda-Valdés, Daniel Cuevas-Ramos, Miguel A. Gómez-Sámano, Bernardo Pérez-Enríquez Pérez-Enríquez, Arturo Abundes Corona, Francisco J. Gómez-Pérez
Keywords
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- EP ID EP333771
- DOI 10.15226/2374-6890/4/2/00176
- Views 127
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