Features of cortisol secretion in adult patients with atopic dermatitis
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 4
Abstract
Оbjective — to determine features of basal cortisol secretion dynamics in atopic dermatitis (AD) patients depending on pathogenesis variant and age of the disease onset. Materials and methods. 63 adult patients with atopic dermatitis were examined: 37 with onset in early childhood, 26 — with onset in puberty or adult period. Severity of the disease, IgE-dependence and morning cortisol secretion level were determined. Results and discussions. Decrease in morning cortisol secretion at the pick of AD relapse was found to be more common in AD patients with the disease start in early childhood. Evident clinical improvement of AD was accompanied with cortisol level close to that in healthy people. Dynamics of cortisol secretion under the treatment was significantly higher in patients with high levels of total IgE. Relationship between morning cortisol level, and AD severity, its clinical variant, as well as age or sex was absent. Conclusions. Difference in hypothalamus-pituitary-adrenal system reaction at adult AD patient depending on age of AD onset and total IgE secretion level was determined. AD patients with early disease onset and high total IgE levels have more severe depletion of cortisol secretion at relapse.
Authors and Affiliations
O. D. Aleksandruk
Keywords
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- EP ID EP454843
- DOI 10.30978/UJDVK2018-4-26
- Views 102
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