Features of cortisol secretion in adult patients with atopic dermatitis
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 4
Abstract
Оbjective — to determine features of basal cortisol secretion dynamics in atopic dermatitis (AD) patients depending on pathogenesis variant and age of the disease onset. Materials and methods. 63 adult patients with atopic dermatitis were examined: 37 with onset in early childhood, 26 — with onset in puberty or adult period. Severity of the disease, IgE-dependence and morning cortisol secretion level were determined. Results and discussions. Decrease in morning cortisol secretion at the pick of AD relapse was found to be more common in AD patients with the disease start in early childhood. Evident clinical improvement of AD was accompanied with cortisol level close to that in healthy people. Dynamics of cortisol secretion under the treatment was significantly higher in patients with high levels of total IgE. Relationship between morning cortisol level, and AD severity, its clinical variant, as well as age or sex was absent. Conclusions. Difference in hypothalamus-pituitary-adrenal system reaction at adult AD patient depending on age of AD onset and total IgE secretion level was determined. AD patients with early disease onset and high total IgE levels have more severe depletion of cortisol secretion at relapse.
Authors and Affiliations
O. D. Aleksandruk
Keywords
Related Articles
- EP ID EP454843
- DOI 10.30978/UJDVK2018-4-26
- Views 83
- Downloads 0
Probiotics in dermatology
Probiotics are live microorganisms that, when administered in adequate amounts, may confer a health benefit on the host. We already know that their use is positively influencing key factors in the development of dermatol...
Mechanisms of action of activated pyrithione zinc
Activation of zinc pyrithione gives it complementary pharmacodynamic properties — antimicrobial and antifungal effects, which determine its effectiveness in psoriasis and atopic dermatitis. The use of Skin-cap in these d...
State of pituitarythyroid system in patients with acne from iodine deficiency region
Objective — to determine and analyze the state of pituitary-thyroid system in patients with acne disease (AD) who live in the region with natural iodine deficiency. Materials and methods. We have examined 114 patients w...
15th Spring Symposium of the European Academy of Dermatology and Venereology
15th Spring Symposium of the European Academy of Dermatology and Venereology
Case of chronic balanoposthitis with detection of Pentatrichomonas hominis
A clinical case is presented — a man with manifestations of chronic urethritis and balanoposthitis, probably caused by Pentatrichomonas hominis. Consistent treatment with ornidazole and nifurоtel in the background of ext...