FETAL PROGRAMMING AND METABOLIC SYNDROME
Journal Title: Българско списание за обществено здраве (Bulgarian Journal of Public Health) - Year 2017, Vol 0, Issue 1
Abstract
Metabolic Syndrome (MS) is being observed with increased frequency and being overweight plays a central role in its occurence and development. It is an undisputed fact that a super-nutritious diet and lack of exercise are the most obvious factors. A prerequisite for this could be also intrauterine and perinatal factors leading to development of SGA (Small for Gestational Age) newborns with consequent catch-up growth or LGA ( Large for Gestational Age) new-borns especially in patients with gestational diabetes. The adverse environmental conditions could cause not only vascular, physiological, metabolic and epigenetic changes and slow down in the growth of the fetus but also could be a reason for permanent and irreversible systematic and organic changes that occur in juvenile and grown-up individual who are prone to cardiovascular and metabolic diseases. These are examples of fetal (re)programming with longterm consequences quo ad vitam. The basis of these processes is found in epigenetic changes, due to fetal plasticity and adaptation during fetal development.
Authors and Affiliations
Velislava GEORGIEV
Keywords
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