FLT3-ITD mutation and its correlations with clinical and hematological features in adult patients with acute myeloid leukemia – preliminary report
Journal Title: Postępy Nauk Medycznych - Year 2013, Vol 26, Issue 3
Abstract
<b>Introduction. </b><i>FLT3</i> gene, encoding receptor tyrosine kinase (RTK), is expressed in hematopoietic progenitor cells. After interaction of RTK with its ligand it regulates cell proliferation and differentation. In leukemic cells ligand – independent activation is frequently observed. It is mainly caused by internal tandem duplication (ITD) of <i>FLT3</i>. <i>FLT3</i>-ITD mutation occurs in 20-30% of acute myeloid leukemia (AML) patients and is an independent, unfavorable prognostic factor, helpful in patients stratification.<br><b>Material and methods.</b> We analyzed bone marrow cells from 73 patients with AML (32 women and 41 men). Molecular and cytogenetic analyses were done simultaneously to evaluate mutation and chromosomal aberrations. Patients were categorized according to karyotype results to good, intermediate and poor prognostic groups.<br><b>Results.</b> <i>FLT3</i>-ITD was detected in 7 patients with intermediate and in 4 with poor cytogenetic risk. Mutation was not found in patients with favorable karyotype. Kaplan-Meier survival analysis revealed higher probability of longer overall survival in patients without <i>FLT3</i>-ITD mutation, independently of karyotype.<br><b>Conclusions.</b> <i>FLT3</i>-ITD mutation classifies patients to poor risk group regardless of karyotype. It also negatively affects treatment results.
Authors and Affiliations
Karolina Matiakowska, Małgorzata Morgut-Klimkowska, Alicja Bartoszewska-Kubiak, Krystyna Soszyńska, Barbara Mucha, Katarzyna Skonieczka, Patryk Różycki, Maria Czyżewska, Grażyna Gadomska, Olga Haus
Keywords
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