Follicle Stimulating Hormone, Luteinizing Hormone, Prolactin, Progesterone and Testosterone Level in Chlamydia Trachomatis Infected Subject
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Background: Chlamydia trachomatis (Ct) is an obligate intracellular gram negative bacterial pathogen. Ct infection is a major and increasing public health problem worldwide. Currently, is the main cause of sexually – transmitted infection. Aim: The aim of this study is to compare the serum level of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PL), progesterone and testosterone in Chlamydia trachomatis positive patients, ct negative patients with infertility and control subjects without infertility and Chlamydia infection Materials and methods: Two hundred patients that are clinically confirmed with primary and secondary infertility and 50 control subjects with no history of infertility were included. Chlamydia assay was done by Enzyme Immunosorbent Assay (EIA). FSH, LH, PL, progesterone and testosterone were measured by Enzyme Linked Immunosorbent Assay (ELISA). Results: The mean ± S.D. of FSH (IU/ml), LH (IU/ml) in male infertility with positive Chlamydia trachomatis (Ct) infection and negative Chlamydia trachomatis infection respectively were compared with fertile male control subjects. The result showed statistically higher significance difference in the male infertility compare with the normal (F=7.15; P =0.01, F=3.24; P = 0.04). The mean ± S.D. of FSH (IU/ml), progesterone (IU/ml) in female infertility due to positive Chlamydia trachomatis (Ct) infection, and the negative Chlamydia trachomatis infection respectively were compared with and fertile female control. The FSH result showed statistically higher significant difference in infertility compared with fertile counterpart (F=3.8; P = 0.025), while progesterone showed lower significant difference in infertility compared with normal control (F=4.48; P = 0.01). The prolactin and testosterone compared among the three groups in both male and female showed no significant difference. Conclusion: In this study, follicle stimulating hormone was elevated in male infertility while progesterone level was significantly low in female infertility.
Authors and Affiliations
Ifeanyichukwu Martin Ositadinma, Dele-Ochie Patricia Ejenawome, Ebunu Ezekiel, Inege Lucky Chukwudi, Ngwu Amauche Martina 4
Keywords
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- EP ID EP383988
- DOI 10.9790/3008-1102037174
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