FORMULATION AND EVALUATION OF ATOMOXETINE HCL MUCOADHESIVE MICROSPHERES
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
Atomoxetine HCl is a potent inhibitor of the presynaptic norepinephrine transporter with minimal affinity for other monoamine transporters or receptors and is the first non-stimulant medication approved for the management of attention deficit/hyperactivity disorder (ADHD) in children, adolescents and adults. Drug formulating into mucoadhesive microspheres is a modern and a more innovative approach used widely to prolong the drug release pattern and also for targeted drug release.The plasma half of Atomoxetine range is 5.2hrs and the dosage regimen according to FDA dosing guide is start at 40 mg, target at 80mg, maximum 100mg twice a day. Hence, Atomoxetine was chosen as a model drug for prolong action and to improve patient compliance. Atomoxetine HCl mucoadhesive microspheres were prepared by ionotropic gelation technique. The mucoadhesive microspheres were prepared with different polymers, i.e, Sodium alginate, pectin and karaya gum with different combinations. From the studies conducted in this work, it can be concluded that the release of Atomoxetine Hydrochloride can be retarded by encapsulating it in calcium alginate spheres. The optimum formulation, Drug–Sodium alginate–Kharaya gum (1:0.75:0.75) mucoadhesive spheres demonstrated controlled release of the drug for 10hrs and exhibited good mucoadhesive property. The FTIR studies revealed the absence of the drug –polymer interaction in the solid state. The formulated mucoadhesive microspheres of Atomoxetine Hydrochloride can control the drug release; it has good mucoadhesive property and can improve the bioavailability of the drug.
Authors and Affiliations
Meneshwari Mohan , Hazari Sujitha1 , V. Uma Maheshwara Rao2 , Ramavath Naresh Naik , B. Arun Kumar1
Keywords
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