Formulation and Evaluation of Chitosan -Polyvinyl Alcohol nanocomposites for Controlled Release of Catharanthus Roseus Extract
Journal Title: Journal of Advance Nanobiotechnology - Year 2017, Vol 1, Issue 1
Abstract
In this present work, chitosan (CS) crosslink polyvinyl alcohol (PVA) with montmorilonite (MMT) called as (CS-PVA/MMT) and CS with PVA without MMT (CS-PVA) were prepared by solution casting method. Further the formation of nanocomposites CS-PVA/MMT and CS-PVA were investigated using XRD, and tensile strength. Water uptake and swelling ratio of the CS-PVA and CS-PVA/MMT were found to decrease with increase in concentration of clay. Mechanical properties of the CS-PVA and CS-PVA/MMT were assessed in terms of tensile strength and extensibility using texture analyzer. In vitro drug release study on CS-PVA and CS-PVA/MMT indicated pronounced sustained release of Catharanthus roseus extract (CRE) by the incorporation of clay particles in the CS polymer matrix. Overall CS-PVA/MMT nanocomposite films exhibited improved mechanical and sustained drug release properties than CS-PVA.
Authors and Affiliations
Umakanta Sahoo
Keywords
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- EP ID EP290413
- DOI 10.28921/jan.2017.01.05
- Views 133
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