Preparation and Characterization of Cassava Starch - Polyvinyl Alcohol nanocomposites for Control Drug Release of Paclitaxel
Journal Title: Journal of Advance Nanobiotechnology - Year 2017, Vol 1, Issue 1
Abstract
In this study, we developed encapsulating Paclitaxel drug in Cassava starch - Polyvinyl alcohol/cloisite 30B [PLX-CSH-PVA/C30B] nanocomposites. CSH-PVA/C30B was characterized by FTIR, XRD. The PLX-loaded CSH-PVA/C30B was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release proļ¬le. Additionally, drug entrapment efficacy (EE) was up to 66%; CSH-PVA/C30B showed a pH-responsive drug release in vitro. The PLX release was nearly 74% at pH 4.4 and 68% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery, Bio Sensor Manufacturing, Medical therapy and the development of PLX-CSH-PVA/C30B nanocomposites for sustained, controlled release and may be useful for breast cancer treatment.
Authors and Affiliations
Swati Mohanty
Keywords
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- EP ID EP290408
- DOI 10.28921/jan.2017.01.03
- Views 93
- Downloads 0
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