Gelatin-Coated Silver Nanoparticles for Controlled Released of Anticancer Drug Cyclophosmide
Journal Title: Journal of Advance Nanobiotechnology - Year 2017, Vol 1, Issue 1
Abstract
In this study, we developed encapsulating cyclophosmide (CYC) drug loaded gelatin (GL) coated O. basilicum L mediated gold nanoparticles (O-AgNPs) [CYC loaded CS coated-O-AgNPs]. O-AgNPs were characterized by UV-Visible spectrophotometer, FTIR, XRD .The CYC-loaded GL coated-O-AgNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release pro?le. Additionally, drug entrapment efficacy (EE) was up to 66%; GL- O-AgNPs showed a pH-responsive drug release in vitro. The CYC release was nearly 74% at pH 5.4 and 65% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery, Bio Sensor Manufacturing, Medical therapy and the development of CYC-loaded CS coated-V-AgNPs nanoparticle for sustained, controlled release and may be useful for breast cancer treatment.
Authors and Affiliations
Shikha Behera
Keywords
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- EP ID EP290411
- DOI 10.28921/jan.2017.01.04
- Views 97
- Downloads 0
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