FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ZIDOVUDINE
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 4
Abstract
Zidovudine is considered a good candidate for incorporation in a gastro-retentive dosage form due to its high solubility in the stomach medium compared with its solubility in the small intestine medium. As its solubility decreases with increase in pH, it would be more beneficial to retain the drug in stomach (acidic environment) for prolonged duration so as to achieve maximum absorption and bioavailability. Zidovudine is the first approved compound for the treatment of aids; however the limitation for the therapeutic effectiveness of zidovudine is its dose-dependent toxicity, short biological half-life and poor bioavailability. The present research work, an attempt has been made to develop the zidovudine gastro-retentive dosage form for controlled release.
Authors and Affiliations
M. Alekhya , N. Swapna , CH. Sirisha , CH. Gayathri , M. Anusha
Keywords
Related Articles
- EP ID EP122775
- DOI -
- Views 142
- Downloads 0
DEVELOPMENT AND VALIDATION OF LORATADINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROSCOPIC METHOD
A simple UV spectroscopic method was developed and validated for the estimation of loratadine in bulk and pharmaceutical dosage form using acetonitrile as solvent. The quantification was achieved at 250nm. Beers la...
COMPARATIVE STUDY OF LOCAL CONCENTRATE WITH IMPORT CONCENTRATE INCLUSION IN BROILER CHICKS DIETS
A total of 120 broiler chicks, were used in this experiment to evaluate the effect of feeding local concentrate replaced the imported concentrate on the performance of broiler chicks. Three dietary treatments were...
EFFECT OF EXCIPIENTS AND PROCESS VARIABLES OVER GASTRO RETENTIVE ANTIHYPERTENSIVE DOSAGE FORM
The objective of this study was to formulate an oral floating tablet of Captopril using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC) and Carbopol 934P gas generating agent Calcium Carbonate and...
ANALYTICAL STUDY OF PROCESSING UTILITY AND SOME PHYSICO-CHEMCIAL PARAMETERS OF RAW WATER, SOFT WATER AND DEMINERALIZED WATER IN KORBA AREA
World Water & Environmental Engineering is an international water quality magazine that reaches over 10,000 water quality professionals in Central India and South India. Helmed by London-based publisher Nic Chr...
DEVELOPMENT AND VALIDATION OF A RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ENALAPRIL MALEATE AND RAMIPRIL IN BULK AND TABLET DOSAGE FORM
A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Enalapril maleate and Ramipril in bulk and tablet dosage form. Chr...