Abstract

Atenolol is an antihypertensive drug and the elimination half life is 3-4 hours. The main aims of prepared Atenolol floating tablets are to increase the retention time in gastric and also to improve the bioavailability. Atenolol was selected as a drug because it is incompletely absorbed from the gastrointestinal tract and has an oral bioavailability of only 50% while remaining drug is excreted unchanged in feces. This is because of poor absorption in lower gastrointestinal tract. The floating Atenolol tablets were formulated by using HPMC K100M, HPMC K4M, HPMC K15M as the release retardant polymers, and sodium bicarbonate used as a gas generating agent to reduce the floating lag time. Direct compression method was used to prepared the tablets and then evaluated for friability, hardness, weight variation, total floating time, floating lag time, dissolution rate.

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