FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF AMLODIPINE BESYLATE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 4
Abstract
Recent advances in technology have presented viable dosage forms alternative for patients who may have difficulty in swallowing tablets or capsules. Oro-dispersible tablet is one such approach in which the tablets were dispersed in the mouth rapidly. Amlodipine is a calcium channel blocker used in the treatment of hypertension and angina pectoris, where ultra-rapid action is required. In the present study Amlodipine Oro-dispersible tablets are formulated using sodium starch glycolate, croscarmellose sodium, crospovidone superdisintegrants. The tablets were prepared by direct compression technique and were evaluated for weight variation, friability, hardness, drug content, in-vitro disintegration time, wetting time, in-vitro dissolution studies. All the formulations follow compendia specifications. Formulations containing higher concentrations of sodium starch glycolate and cross povidone as superdisintegrant showed better dissolution profile and disintegration time. The bioavailability of amlodipine was increased by formulating amlodipine as ODT. Differential Scanning calorimetric study (DSC) and Fourier transform infrared spectroscopy (FTIR) were conducted for drug excipient compatibility study.
Authors and Affiliations
Shobha Krushnan G, Ravi M Britto, Perianayagam J, Rajendra Prasad R
Keywords
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