FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF CINNARIZINE BY SUPER DISINTEGRANTS ADDITION METHOD
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
The aim of the present work is to study the Preformulation parameters for Cinnarizine orodipersible tablet. The objective of pre-formulation study is to generate information useful to the formulator in developing stable and bioavailable dosage form. Administration of conventional tablets of Cinnarizine has been reported to exhibit fluctuations in plasma drug levels, either in manifestation of side effects or reduction in drug concentration at the receptor sites. Conventional Cinnarizine tablets available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by the geriatric and pediatric patients who experience difficulty in swallowing, and by those who are bed ridden or who are traveling and do not have an easy access of water. Usage of excipients like low-substituted hydroxypropyl cellulose, crospovidone helps for the faster disintegration and faster release of the drug from the dosage form. The Preformulation studies were carried out in terms of test for identification (physical appearance, melting point, and UV spectrophotometer), solubility profile, and determination of partition coefficient and quantitative estimation of drug. All the observations and results showed that the Cinnarizine could serve as suitable candidate for fast dissolving tablet that may improve the bioavailability.
Authors and Affiliations
Praveen Khirwadkar Kamlesh Dashora Shyam Bihari Sharma
Keywords
Related Articles
- EP ID EP33066
- DOI -
- Views 284
- Downloads 0
Neuroprotective profile of mulberry leaf extract in focal cerebral ischemia model in rats
The cerebral ischemia causes severe degree of oxidative stress as a result of reperfusion injury. An attempt has been made to analyze the preventive and curative potential of mulberry leaf extract, in focal cerebral is...
A comprehensive review on solid dispersion technique for the enhancement of bioavailability of poorly soluble drugs
Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poorly water soluble drugs often require high doses in order to re...
Formulation and evaluation of losartan potassium ethosomal gel
Clinically liposomal systems were found to be effective, at forming drug reservoir in the upper layers of the skin for local skin therapy. Recently, it was found that Ethosomal carriers were phospholipid vesicular syst...
Innovations in Nanotechnology in Water purification
A grand challenge of the 21st century is providing clean and potable water to meet human needs. By population growth, global climate change, and water quality deterioration worldwide, water supply struggles to keep up...
Development and validation of a stability indicating HPLC method for analysis of Altretamine in bulk drug and pharmaceutical formulations
A simple, sensitive and accurate stability indicating HPLC method has been developed and validated for determination of Altretamine in its bulk form and pharmaceutical formulations. Chromatographic separation was achie...