Formulation and evaluation of Orodispesible tablets of Aripiprazole tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 6
Abstract
The aim of present work was to prepare mouth dissolving tablets of Aripipazole tablets, used it is atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder.. The demand of fast disintegrating tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The objective of the present study is to prepare fast disintegrating tablets of Aripiprazole by using different disintegrants for the potential emergency treatment of schizophrenia. The superdisintegrant used in this study were crosspovidone, crosscarmelose sodium and Sodium Starch Glycolate in varying concentrations. . spray dried mannitol was used as diluent. Aspartame and lemon flavor were used to enhance organoleptic properties of the tablets. The formulated tablets were evaluated for weight variation, wetting time, hardness, friability and in vitro disintegration time, In vivo disintegration time and drug release characteristics. Results of In vitro disintegration time and In vivo disintegration time indicated that the tablets dispersed (or) disintegrate rapidly within 16 seconds, also the hardness, friability, dissolution rate and assay of prepared tablets were found to be acceptable according to standard limits.
Authors and Affiliations
K. Vinod kumar, B Pragati Kumar
Keywords
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