Formulation and Evaluation of Perindopril Erbumine Buccal Films
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
The buccal region of the oral cavity is an attractive target for administration of the drug of choice. To increase bioavailability and prevent first pass metabolism of drug, Perindopril Erbumine was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of HPMC with Eudragit, sodium CMC and EC for water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and polymer. The mucoadhesive strength and in-vitro released of water soluble drug through water insoluble HPMC base matrix were found satisfactorily. The physical appearance of buccal patch was examined by scanning electron microscopy. In the present study, attempts were made to prepare and evaluate the Buccal films containing Perindopril hydrochloride, an antihypertensive drug using Hydroxy propyl methyl cellulose, Eudragit RL-100, Eudragit RS-100, Dichloro-Methane, Methanol. The results showed that buccal patches prepared Using 15% propylene glycol w/w of polymer weight was found to have good physical characteristics. A remarkable increase in thickness, FTIR, drug content uniformity, drug release and stability studies percent swelling index, percent moisture uptake and mechanical properties with an increase in the percent hydrophilic polymer (HPMC). All the patches were, thin, smooth and flexible, uniformity in drug content, weight and thickness were observed with their low SD values. In-vitro drug permeation through sheep buccal mucosa was performed using Franz diffusion cells. The film showed maximum permeation at the end of 6 hrs. The release mechanism from all membrane controlled systems followed diffusion mechanism. All the systems were found to be stable with respect to drug content as well as physical changes at 400C and 75% RH.
Authors and Affiliations
M. Aruna, Y. S. Manjunath, G. Ganesh Kumar
Keywords
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