Formulation and in-vitro evaluation of extended release matrix tablets of Mefenamic acid
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 4
Abstract
Extended release formulations make the drug available over extended time period after oral administration. The Extended release will optimize therapeutic effect and safety of a drug at the same time improving the patient convenience and compliance. By incorporating the dose for 24hrs into one tablet from which the drug is release slowly, in this study the extended release tablet of Mefenamic acid were prepared, Hydroxy propyl methyl cellulose E 15, sodium carboxy methylcellulose sodium were used as extended releasing polymer during dissolution. During study, different drug to polymer ratios were formulated. In the present research work Mefenamic acid was selected as a model drug, as it has oral bioavailability of 70%, has short half-life of 2 to 3 hours and BCS Class – II drug. These parameters made it suitable drug candidate for the preparation of the extended release matrix tablet formulation. The tablets from different formulation were evaluated for uniformity of weight variation, hardness, friability, thickness, content uniformity, in-vitro dissolution, and drug-excipients interaction. All the parameters were found within pharmacopeial limits. Moreover various co-excipients such as lactose, talc, magnesium stearate etc. were added in the formulation and their effect on the release profile was investigated. Among the different formulations F7 is the optimized formula, the release of drug up to 100.19%.
Authors and Affiliations
V. Himabindu, Reddy Sunil, A. Venkatesham
Keywords
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