Abstract

Abstract In the present research work floating pulsatile drug delivery system of dofetilide were prepared using various grades of methocel polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of Methocel. The formulation blend was subjected to various pre-formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Methocel K 4 M were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. Whereas the formulations prepared with Methocel K 15 M retarded the drug release in the concentration of 60 mg (F6) showed required release pattern i.e., retarded the drug release up to 10 hours and showed maximum of 98.97 % in 12 hours with good floating lag time and floating buoyancy time.. The formulations prepared with Methocel K 100 M showed more retardation even after 12 hours they were not shown total drug release. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order kinetics.

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