FORMULATION OF KETOCONAZOLE OPHTHALMIC OINTMENT USING COW GHEE AS A BASE AND PENETRATION ENHANCER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 7
Abstract
The present work is concerned with the study of cow ghee as penetration enhancer in ketoconazole ophthalmic ointment as an ointment base with respect to conventional ointment base. Ophthalmic ointment was prepared with 1% ketoconazole, 0.01% w/v Benzalchonium chloride and butylated hyroxytoluene B.P (0.02%) with cow ghee as a base as well as petrolatum base and investigated their usefulness in the ophthalmological field by evaluating pH, acid value, freeze thaw cycle, isotonicity, corneal toxicity and in vitro transcorneal permeation study using excised goat cornea. cow ghee is an effective penetration enhancer as an ointment base. The interaction study between ketoconazole and cow ghee were found to be negative. Evaluation parameters such as pH, acid value, freeze thaw cycle, isotonicity, were carried out. Overall results suggest that cow ghee is safe for use as a penetration enhancer in ophthalmic delivery system as an ointment base.
Authors and Affiliations
Monali Dumore , Mahesh Mishra , Nitin Dumore , Ujwala Mahajan
Keywords
Related Articles
- EP ID EP144143
- DOI 10.7897/2230-8407.07781
- Views 109
- Downloads 0
PHYTOCHEMICAL CONSTITUENTS OF PHYLLANTHUS SPECIES (EUPHORBIACEAE) FROM EASTERN GHATS OF ANDHRA PRADESH, INDIA
The present paper deals with phytochemical constituents of Phyllanthus species (Euphorbiaceae). The petroleum ether, methanol and water extracts of different parts of 15 species of Phyllanthus were screened for phytochem...
A VALIDATED REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF DOXOFYLINE IN PURE AND PHARMACEUTICAL FORMULATIONS
A novel reverse phase high performance liquid chromatographic method (RP-HPLC) was developed and validated for the determination of doxofylline (DXF) in pharmaceutical formulations. Agilent 1100 series HPLC instrument eq...
PREPARATION AND EVALUATION OF MONTELUKAST ORAL DISPERSIBLE TABLETS BY DIRECT COMPRESSION METHOD
The purpose of this research was to develop oral dispersible tablets of montelukast sodium. Montelukast sodium is most commonly used in treatment of Asthma. Oral dispersible tablets were prepared by using a direct compre...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DIAZEPAM AND PROPRANOLOL HYDROCHLORIDE IN COMBINED DOSAGE FORM
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of diazepam and propranolol hydrochloride in combin...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ELETRIPTAN IN ELETRIPTAN HYDROBROMIDE ORALLY DISINTEGRATING TABLETS
A simple, precise, rapid and accurate stability indicating reverse phase high performance liquid chromatography has been developed and validated for the estimation of Eletriptan Hydrobromide in tablet dosage form. Separa...