FORMULATION OPTIMIZATION AND EVALUATION OF LIPOSOMAL GEL OF PREDNISOLONE BY APPLYING STATISTICAL DESIGN
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Liposomal carriers, well known for their potential in topical drug delivery have been chosen to help Prednisolone molecules in the skin layers. In the present work statistical study for the formulation of liposomes for topical delivery of Prednisolone using the factorial design approach was undertaken. Amount of Soya Lecithin, DPPS and cholesterol (CH) were taken at three different levels and liposomes were prepared using film hydration technique. Gels containing liposomes (optimized batch) were prepared in Carbopol® 940P and were characterized for rheology, spreadability and permeation through the rat skin. Results of regression analysis revealed that vesicle size and entrapment efficiency were dependant on the cholesterol and lipid concentration. Rheological studies of all liposomal gels prepared with 1%, 1.5%, and 2% w/w carbopol gave a clear idea of concentration of carbopol required. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control and marketed gel. Liposome dispersion and gel formulation were found to be stable for 60 days.
Authors and Affiliations
Varde Neha M, Thakor Namita M, C. Sini Srendran, Shah Viral H
Keywords
Related Articles
- EP ID EP33050
- DOI -
- Views 314
- Downloads 0
MORBIDITY PATTERN AMONG THE ELDERLY POPULATION IN A SOUTH INDIAN TERTIARY CARE INSTITUTION: ANALYSIS OF A RETROSPECTIVE STUDY
A retrospective study of the morbidity profiles among the elderly and an assessment of the related factors are required to plan an appropriate geriatric health care service. The present study also sought to determine th...
Development and in-vitro evaluation of controlled released tablets of Metoprolol succinate
The objective of the present study was to develop controlled-release matrix tablets of metoprolol succinate, β1- selective adrenergic receptor blocking agent. The tablets were prepared by the wet granulation method. Eth...
Fluidized bed processing: A review
The formulation development is the key step in the success of a formulation to sustain in the present day market. Such formulation development is emerging new technologies for the development of products via innovative...
Formulation and evaluation of transdermal patches of Irbesartan
The purpose of the research was to develop matrix type transdermal therapeutic system containing irbesartan with different ratios of hydrophilic and hydrophobic polymeric concentration by the solvent evaporation techni...
Design and development of Metformin hydrochloride Trilayered sustained release tablets
Diabetes is one of the major causes of death and disability in the world. Diabetes results from decreased secretion of insulin, decreased insulin action or both. The main aims of the investigation was to design and dev...