FORMULATION OPTIMIZATION AND EVALUATION OF LIPOSOMAL GEL OF PREDNISOLONE BY APPLYING STATISTICAL DESIGN
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Liposomal carriers, well known for their potential in topical drug delivery have been chosen to help Prednisolone molecules in the skin layers. In the present work statistical study for the formulation of liposomes for topical delivery of Prednisolone using the factorial design approach was undertaken. Amount of Soya Lecithin, DPPS and cholesterol (CH) were taken at three different levels and liposomes were prepared using film hydration technique. Gels containing liposomes (optimized batch) were prepared in Carbopol® 940P and were characterized for rheology, spreadability and permeation through the rat skin. Results of regression analysis revealed that vesicle size and entrapment efficiency were dependant on the cholesterol and lipid concentration. Rheological studies of all liposomal gels prepared with 1%, 1.5%, and 2% w/w carbopol gave a clear idea of concentration of carbopol required. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control and marketed gel. Liposome dispersion and gel formulation were found to be stable for 60 days.
Authors and Affiliations
Varde Neha M, Thakor Namita M, C. Sini Srendran, Shah Viral H
Keywords
Related Articles
- EP ID EP33050
- DOI -
- Views 310
- Downloads 0
Home diagnostics: a snapshot of public views in the state of Andhra Pradesh, level of awareness and use
Even though the public are better educated than earlier with their health conscious through awareness and demonstration camps they averse to attend clinical labs for petty diagnostic tests since it costs much apart fro...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF CINNARIZINE BY SUPER DISINTEGRANTS ADDITION METHOD
The aim of the present work is to study the Preformulation parameters for Cinnarizine orodipersible tablet. The objective of pre-formulation study is to generate information useful to the formulator in developing stabl...
A Review on various HPLC and Spectrophotometric methods for determination of Atenolol and Nifedipine in combined formulations
Atenolol and Nifedipine in combination are used as Anti – hypertensives. High blood pressure is a chronic medical condition in which the blood pressure in the arteries is elevated. Atenolol competes with the sympathomi...
Formulation and evaluation of biodegradable Ondansetron hydrochloride implant
Implantable drug delivery systems are used to deliver drugs for longer period of time, beneath the skin. These drug delivery systems are implanted subcutaneously and drug is supposed to be released in sustained manner...
Formulation and Evaluation of Irbesartan Microspheres
In the present work, microspheres of Irbesartan using sodium alginate as a retarding polymer were formulated to deliver Irbesartan via oral route. The results of this investigation indicate that solvent evaporation met...