Genetic Polymorphismof IraqiLeishmania tropicaIsolates Based on HSP70Gene
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Leishmaniasis is one of the important parasitic diseases, affecting mainly low social class people in developing countries, and is more prevalent and endemic in the tropical and subtropical regions of old world and new world. Despite ofbroad distribution in Iraq,little known about the geneticcharacteristics of the causative agents. So this study was aimed to evaluate the genetic varietyoftwo IraqiLeishmaniatropicaisolates based on heat shock protein gene sequence 70 (HSP70) in comparison with universal isolates recorded sequences data. After amplification and sequencing of HSP70 gene,the obtainedresults were alignment along with homologous Leishmania sequences retrieved from NCBI by using BLAST. The analysis results showed presence of particular gene mutations including substitution and insertion at 93% identity with the HSP70 gene. So,indicate the prescient of numeric variation of local isolate and this is the first step toward future phylogenic study to understand genomic diversity across Leishmania tropica parasite.
Authors and Affiliations
Duha Muhanad Bayram, Hayder Z. Ali
Keywords
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