ГІПОГЛІКЕМІЧНІ ВЛАСТИВОСТІ АМІНОКИСЛОТНИХ СПОЛУК ХРОМУ(ІІІ)
Journal Title: World Science - Year 2018, Vol 2, Issue 2
Abstract
The coordination complex of chroium (III) with bidentate coordinated cysteine [Cr(HCys)3]×3H2O has been synthesized. According to the IR spectra results, the coordination of the amino acid takes place throught the carboxyl group oxygen and amino group nitrogen: 3070 сm-1 and 3190 сm-1 (ν(NH2)); 496 сm-1 (ν(Cr-N)); 1612 сm-1 (νas(COO-)); 1370 сm-1(νs(COO-)); 570 сm-1 (ν(Cr-O). The gipoglikemichecal activity and toxic properties of chromium (III) and cysteine compound have been studied. It was established, that the intracavitary injection of 1 mg/kg dose oftris-hidrotsisteynat chromium (ІІІ) in white mice, decreased the level of glucose in their blood by 45 %. The [Cr(HCys)3]×3H2O complex reduces glucose better than other chormium (III) - amino acids compounds. The complex tris-hidrotsisteynat chromium (ІІІ) is easily synthesized, has a pH value of 4,8 – 5. Indicator LD50 was calculated and is 2568 mg/kg. The compound of chromium (III) with cysteine is slightly toxic and belongs to grade IV toxicity. The toxicity index of the amino acid complexes of chromium (III) varies in the series of compounds [Сr(HСys)3]×H2O > [Сr2(Nik)2(OH)4]×4H2O @ [Сr(Gly)3]×H2O > [СrАsp(ММSCl)2 and is substantially lower than that of inorganic chromium (III) salts.
Authors and Affiliations
О. О. Чернушенко, О. В. Саєвич
Keywords
Related Articles
- EP ID EP410667
- DOI -
- Views 64
- Downloads 0
HISTORY OF THE STATE ARCHIVES OF THE WEST KAZAKHSTAN REGION
.
АКТУАЛЬНІСТЬ ВИВЧЕННЯ НАВЧАЛЬНОЇ ДИСЦИПЛІНИ «МЕНЕДЖМЕНТ КУЛЬТУРИ І МИСТЕЦТВА» НА МУЗИЧНИХ ФАКУЛЬТЕТАХ ВИЩИХ НАВЧАЛЬНИХ ЗАКЛАДІВ
The article is dedicated to the urgency of the study of the student course «Management of culture and art» in Faculties of Music of Ukrainian higher educational establishments. The author analyses the experience of its s...
ОСОБЛИВОСТІ ІНФОРМАЦІЙНО-УПРАВЛЯЮЧИХ СИСТЕМ ЛОГІСТИКИ В РОЗРІЗІ ЇХ ПІДСИСТЕМ
The place of information management system`s subsystems of trade organizations logistics in the enterprise information system is considered here. Particular attention is paid to the description of subsystems and the defi...
ВНЕШНЕТОРГОВАЯ ДЕЯТЕЛЬНОСТЬ ПРЕДПРИЯТИЙ В УСЛОВИЯХ ГЛОБАЛИЗАЦИИ
The article considers the foreign economic activity of the Republic of Kazakhstan, which represents a set of directions, forms and methods of trade-economic, scientific-technical cooperation, and currency and financial r...
ІННОВАЦІЙНІ ТЕХНОЛОГІЇ ВИПЕРЕДЖАЮЧОГО РОЗВИТКУ СИСТЕМИ ВИЩОЇ ТЕХНІЧНОЇ ОСВІТИ НА ЗАСАДАХ ДИВЕРСИФІКАЦІЇ
The article actualizes the importance of innovative technologies of the advanced development of the system of higher education on the principles of diversification; the features of the influence of diversification on the...