Haemodynamic changes with lower dose of Hyperbaric Bupivacaine with Dexmeditomedine and Conventional dose of Hyperbaric Bupivacaine for Subarachnoid Block in Lower Limb Surgeries (Orthopaedic Cases)
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 6
Abstract
Background and Aims: It is universally agreed that the anaesthesia of choice for lower limb surgeries is a subarachnoid block and a sensory level of T – 10 is recommended to provide excellent anaesthesia for the patient. It is well established that opioids has got a prominent analgesic action at the spinal cord level and it can be used safely for subarachnoid block. If you can add a α-2 adrenoreceptor agonist like Dexmeditomedine to hyperbaric bupivacaine (the standard drug used for sub arachnoid block) and thus reduce the dose of bupivacaine used, without compromising on the analgesic effect and haemodynamic changes. Aim of the study: Primary aim: To measure the Haemodynamic changes like Blood Pressure and Pulse rateby adding dexmeditomedine to lower dose Hyperbaric bupivacaineand Hyperbaric bupivacaine alone. Secondary aim: Compare the side effects like nausea, vomiting, sedation, shivering and pruritis. Methods: This study was prospective, randomized, comparative study double blind in nature and conducted after obtaining institutional Ethics Committee approval and written informed consent. The person giving the drug and the monitoring personnel were blinded 60 adult patients of ASA grade I and II aged between 20 – 50 year. Undergoing various elective lower limb (Orthopaedics) surgeries. Results: Dexmeditomedine in a dose of 5µg was used for supplementation spinal Bupivacaine, showed that Haemodynamic changes like blood pressure and pulse rate is more on the bupivacaine group than dexmeditomedine group. Conclusion: 5 µg Dexmeditomedineto 2cc of hyperbaric Bupivacaine 0.5% is associated with lessor incidence of Hypotension and less Bradycardia compare to bupivacaine group had more incidence of hypotension and bradycardia
Authors and Affiliations
Dr Ajith Kumar G
Keywords
Related Articles
- EP ID EP511769
- DOI -
- Views 61
- Downloads 0
Correlation between Spot Urine Protein-Creatinine Ratio and 24-Hour Urine Protein Estimation in Type 2 Diabetes Mellitus Patients Attending A Tertiary Care Centre in Alappuzha
About 20% of cases of chronic renal failure is due to diabetic nephropathy and is the most common cause of end stage renal disease (ESRD) in many countries. Proteinuria is an independent risk factor for renal diseases an...
Evaluation of Awareness of Common Eye Diseases among General Population of Bihar
Objectives: The main objective of this study is to assess the awareness level of common eye related problems in population of Bihar. Material & Methods: a cross-sectional type of study was conducted on 422 general popula...
An Indolent Natural Killer Cell Leukemia Presenting with Bilateral Ankle Arthritis and Low Grade Fever
NK-cells are morphologically similar to other lymphocytes but immunologically different from them. They have variable expression of one or other T-cell markers but essentially not expressing surface or cytoplasmic CD3 ex...
Mean Platelet Volume in Patients with Acute Ischemic Stroke: A Case Control Study
Background: Cerebrovascular diseases (CVD) include some of the most common and devastating disorders. The important risk factors are hypertension, heart disease, atrial fibrillation, diabetes mellitus, cigarette smoking,...
“EUDRAGIT AND CHITOSAN – THE TWO MOST PROMISING POLYMER FOR COLON DRUG DILEVERY”
Polymers occupy a major portion of materials used for controlled release formulations and drug-targeting systems because this class of materials presents seemingly endless diversity in topology and chemistry. This is a c...