HCV antigens expression and inflammatory activity in patients with chronic HCV infection
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 1
Abstract
Chronic type C hepatitis remains a substantial burden to global health problems. It is estimated, that only up to 30% of infected persons effectively eliminate the virus. In the remaining 70-80% chronic infection develops, with threat of all consequences.The aim of the study was to establish the expression rate of HCV antigens (HCVAgs) in liver tissue and to compare it with the degree of inflammatory reaction in the liver of patients chronically infected with HCV.Liver biopsy specimens from 137 patients with chronic HCV infection were studied. The expression of HCV antigens was detected in frozen liver tissue sections by EnVision, DAKO with the use of FITC-labeled human antibodies to HCV antigens.HCVAgs were detected in 67 out of 137 of the specimens examined (48.9%). Total inflammatory activity did not correlate with HCV antigens expression, however local inflammatory reaction was found as a response to abundant HCVAgs expression.The extension of histopathological examination by immunohistochemical analysis of HCVAgs in liver tissue may contribute to broadening of the knowledge of the immunopathogenesis of chronic hepatitis and may be regarded as valuable tool for searching for chronic hepatitis etiology.
Authors and Affiliations
Bożena Walewska-Zielecka
Keywords
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