Hepatic cells and enzymes reactions in wistar rats exposed to x-ray film processing chemicals
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 1
Abstract
Medical images play significant roles in the diagnosis and management of patients. In developing countries darkroom radiography is practiced and involves chemical processing of films using chemical substances known to be toxic when ingested or inhaled. This study aimed at investigating the histological changes and the changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the liver of wistar rats exposed to different concentrations of x-ray film processing chemicals for varying periods of time. Thirty (30) apparently healthy wistar rats of 20-24 weeks, weighing between 190g and 210g were randomly put into five groups, A-E of 6 rats each. Rats in groups A-D were the experimental groups exposed to varying concentrations of the processing chemicals for periods ranging from 15-30 days while rats in the control group E were not exposed to any processing chemical. After each desired period of time, two rats from each group were randomly selected, painlessly sacrificed, the liver harvested and blood sample collected and examine/analyzed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi Anambra State. Results showed that both x-ray film processing chemicals had adverse effects on the ALT and AST liver enzymes and liver tissues of wistar rats exposed to these chemicals. The effects were not significantly affected by the concentration of the solutions but were related to the period of exposure especially for the developer solution. While the major histological effect of the fixer was the dilation of central vein, the developer had varied histological effects. Keywords: Hepatic cells, ALT and AST Liver enzymes, Wistar rats, X-ray film developer, x-ray film fixer
Authors and Affiliations
Chiegwu HU, Ugwuanyi DC, Ogenyi SI, Chuks HC, Mbakwe KL
Keywords
Related Articles
- EP ID EP370926
- DOI -
- Views 73
- Downloads 0
Assessment of serum uric acid and plasma ascorbic acid in Pregnancy induced hypertension
Oxidative stress plays a crucial role in the pathogenesis of various diseases including pregnancy induced hypertension (PIH). Previous studies have suggested that uric acid not only acts as an antioxidant but also act as...
A clinical study on profile of the patients experiencing extra-pyramidal side-effects with the Usage of second generation antipsychotics Effects of second generation antipsychotics
Abstract: There were claims that second generation antipsychotics (SGA) producefewer extra-pyramidal symptoms (EPS) and their EPS profiles were compared.The aim is to compare the treatment emergent EPS and efficacy profi...
Mode of Delivery and Perinatal Outcome in Early Term and Full Term Deliveries
Abstract: To determine effect of mode of deliveries and gestational age on perinatal outcome. This was Prospective Study at Department of Obstetrics & Gynaecology Zenana Hospital, SMS Medical College, and Jaipur from Mar...
Clinical Evaluation of Intravitreal Triamcinolone Acetonide in Diabetic Macular Oedema
The study was carried out to evaluate prospectively the efficacy and safety ofintravitreal Triamcinolone acetonide (IVTA) injection in Diabetic Macular Oedema (DME). Patient who were diagnosed to have DME were enrolled...
The Role of Tomosynthesis and Ultrasound Imaging In Diagnosis of Breast Lesions
Breast cancer comprises (10.4%) of all cancer incidences among women, Imaging is most diagnostic tool used to confirm presence of it, in addition to histopathology investigation. This study aimed to assess tomosynthesis...