Hepatitis C Virus Genotype Distribution in Forensic Cases
Journal Title: Viral Hepatitis Journal - Year 2020, Vol 26, Issue 2
Abstract
Objectives: In this study, we aimed to determine the hepatitis C virus (HCV) genotype and subtypes in blood samples that were determined by polymerase chain reaction (PCR) in autopsy cases. Materials and Methods: The blood samples of autopsy cases that was sent to serological screening to post-mortem microbiology laboratory between years 2014-2018 were recruited. Forty blood HCV-PCR positive autopsy cases were further evaluated including demographic, clinic, laboratory and autopsy features. Results: Thirty-five 35 (87.5%) of the patients were male and 5 (12.5%) were female. The mean age of the patients was 43.1±11.8 years. Of the 40 cases, 18 (45%) were Turkish citizens and 16 (40%) were other nationals. The identity information of 6 cases (15%) could not be determined. Among 40 HCV-positive cases by PCR, the genotype 3 was determined in 11 (27.5%) of the cases, genotype1a in 9 (22.5%) cases, genotype-1b in 7 (17.5%) cases, genotype-2 in 2 (5%) cases and genotype-4 in 2 (5%) cases. In 9 (22.5%) cases, the genotype could not be determined. Conclusion: The most common HCV genotype in our study population was determined to be genotype-3 and the most common genotype in Turkish origin cases was found to be genotype-1a. Post-mortem PCR analysis for HCV infection is feasible and relevant for demonstrating the ongoing infections at death. Monitoring the change in HCV genotype distribution is critical for the development of effective strategies for HCV elimination.
Authors and Affiliations
Nihan Ziyade, Özgür Yanılmaz, Neval Elgörmüş, Murat Nihat Arslan
Keywords
Related Articles
- EP ID EP688798
- DOI 10.4274/vhd.galenos.2020.2019.0016
- Views 115
- Downloads 0
HBV Flare Under Tenofovir Treatment in Chronic Hepatitis B: Case Report
The purpose of chronic hepatitis B treatment is to stop the progression of the disease and prevent cirrhosis and liver cancer that may occur with the progression of the disease. In the current treatment, one of the nucle...
Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients
Objectives: Hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular carcinoma, but the underlying molecular mechanisms are quite complex. In this study, the aim was to reveal the relationship of...
Which is More Important and Insidious in Dialysis Patients? Occult Hepatitis B or Occult Hepatitis C?
Objectives: The aim of this study was to investigate the presence of occult hepatitis B infection (OBI) and Occult hepatitis C infection (OCI) in hemodialysis patients and to determine whether there is an activation in t...
Correlation between Hepatitis C Virus Antibodies in Saliva and Serum: A Safe Method for Epidemiological Studies
Objectives: Hepatitis C virus (HCV) infection is an increasing public health problem in developing countries. A non-invasive method is required as blood sampling is an invasive method for detecting HCV antibodies. In thi...
Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients
Objectives: Hepatitis C virus (HCV) is one of the major causes of global mortality and morbidity. The purpose of our study was to characterize the distribution of HCV genotypes in Şanlıurfa, to see the effect of patients...