HEPATOPROTECTIVE EFFECT OF LEAVES OF MADHUCA LONGIFOLIA (KOENIG) AGAINST PARACETAMOL INDUCED ACUTE LIVER DAMAGE IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The present study was desined to evaluated the hepatoprotective activity of 70% ethanolic extract of leaves of Madhuca longifolia in paracetamol (2gm/kg) induced liver toxicity in albino wistar rats. The paracetamol injected rats were found to be with significantly increased level of biochemical markers like SGPT (Serum glutamate pyruvate transaminase), SGOT, (Serum glutamate oxaloacetate transaminase) ALP (alkaline phosphatases), serum bilirubin (total and direct), total cholesterol and serum triglycerides. The depleted GSH (glutathione) leves and increased lipid peroxidation indicated the involvement of free radicals in the liver toxicity. 70% ethanolic extract at the dose of 20mg/kg and 40mg/kg produced significant reduction in the serum levels of biochemical markers mentioned above. The extract also increased the levels of GSH and significantly decreased the lipid peroxidation. The results of 70% ethanolic extract were comparable with the standard silymarin. These results suggest that 70% ethanolic extract of Madhuca longifolia (Koenig) may possess the potential therapeutic value in the treatment of some liver diseases, which can be attributed to its anti-oxidant action.
Authors and Affiliations
Arun Kumar, Kaushik Biswas, Bhavin A, Babaria, S Ramachandra Setty
Keywords
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