HEPATOPROTECTIVE EFFECT OF LEAVES OF MADHUCA LONGIFOLIA (KOENIG) AGAINST PARACETAMOL INDUCED ACUTE LIVER DAMAGE IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The present study was desined to evaluated the hepatoprotective activity of 70% ethanolic extract of leaves of Madhuca longifolia in paracetamol (2gm/kg) induced liver toxicity in albino wistar rats. The paracetamol injected rats were found to be with significantly increased level of biochemical markers like SGPT (Serum glutamate pyruvate transaminase), SGOT, (Serum glutamate oxaloacetate transaminase) ALP (alkaline phosphatases), serum bilirubin (total and direct), total cholesterol and serum triglycerides. The depleted GSH (glutathione) leves and increased lipid peroxidation indicated the involvement of free radicals in the liver toxicity. 70% ethanolic extract at the dose of 20mg/kg and 40mg/kg produced significant reduction in the serum levels of biochemical markers mentioned above. The extract also increased the levels of GSH and significantly decreased the lipid peroxidation. The results of 70% ethanolic extract were comparable with the standard silymarin. These results suggest that 70% ethanolic extract of Madhuca longifolia (Koenig) may possess the potential therapeutic value in the treatment of some liver diseases, which can be attributed to its anti-oxidant action.
Authors and Affiliations
Arun Kumar, Kaushik Biswas, Bhavin A, Babaria, S Ramachandra Setty
Keywords
Related Articles
- EP ID EP33015
- DOI -
- Views 456
- Downloads 0
Development and evaluation of Bosentan monohydrate loaded lipid-solid dispersions
In the last decade of the last century, solid lipid dispersions (SLD) have been introduced to the literature as a novel carrier system for cosmetic active ingredients and pharmaceutical drugs. SLD consists of biodegrad...
Pharmacognosy and study of trikarshika churna a popular polyherbal antioxidant
Ancient Ayurvedic lexicon highlights a polyherbal formulations trikarshika for appetite enhancing digestive,febiruge action.Trikarshika is made of equal quantity of dried rhizome of Zingiber officinalis roscoe, Root of...
Development and validation of stability-indicating UV spectrophotometric method for determination of Apremilast in bulk and pharmaceutical dosage form
A simple, precise, accurate, cost effective stability indicating UVSpectrophotometric method has been developed for the estimation of Apremilast in bulk and tablet dosage form. Apremilast shows highest λmax at 229.3 nm....
Evaluation of nephro protective activity of methanolic extract of seeds of Vitis vinifera against Rifampicin and carbon tetra chloride induced nephro toxicity in wistar rats
The Objective of the study was to investigate the nephroprotective activity of methanolic extract of seeds of Vitisvinifera (family:vitaceae) against rifampicin induced and carbontetrachloride induced kidney damage in...
In-vitro antimicrobial efficacy of aqueous extract of Areca nut against Enterococcus faecalis
Background and Aim: Successful root canal therapy relies on the combination of proper instrumentation and effective irrigation of the root canal system. The aim of the study was to evaluate out the antibacterial efficac...