High resolution typing of 10/10 HLA alleles in sibling donor/recipient pairs – is it justified by revealing existing mismatches undetected in standard matching?
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 6
Abstract
Introduction. Although low resolution HLA-A, -B and -DR typing is usually sufficient for segregation of haplotypes required for approval of sibling donor for allogeneic hematopoietic cells transplantation (allo-HCT), it does not exclude undetected HLA mismatches.Aim. The aim of this study was to perform high resolution typing of stored DNA samples from those sibling pairs transplanted in the past, whose recipients experienced clinically significant GVHD.Material and methods. High resolution HLA-A, -B, -C, -DR, -DQ typing was performed in 30 patients and their sibling donors qualified according to low resolution HLA typing, who underwent allo-HCT for hematological malignancies in 2003-2012 and developed either grade III-IV acute GVHD (5 pts), extensive chronic GVHD (16 pts), or both of any degree (9 pts).Results. No allelic mismatches were detected in any donor-recipient pair. Acute grade III-IV and/or extensive chronic GVHD were present in 10 and 21 pts, respectively, despite the complete matching of 10/10 alleles HLA alleles. In 13 pts (43%) clinically significant GVHD has led to fatal post-transplant course, remaining 17 pts are alive.Conclusions. Standard procedures used for matching of sibling donor-recipient pairs are sufficient, although they cannot exclude mismatched HLA alleles.
Authors and Affiliations
Monika Dzierżak-Mietła, Mirosław Markiewicz, Agnieszka Karolczyk, Patrycja Zielińska, Anna Koclęga, Krzysztof Białas, Sławomira Kyrcz-Krzemień
Keywords
Related Articles
- EP ID EP77404
- DOI 10.5604/08606196.1157907
- Views 178
- Downloads 0
Medicalization of Depression, Anxiety, Schizophrenia, ADHD, Childhood Bipolar Disorder and Tantrums: Scientific Breakthrough, or Broad-Based Delusion?
Clearly, a number of psychological and behavioral disorders arise within our biology. These include autism, Down’s syndrome, those due to toxin exposure, metabolic and endocrine difficulties, and several ot...
Smarts as a problem of emergency medicine
The use of drugs is complex, nonhomogeneous and dynamic phenomenon. From time to time new trends appears on the narcotics scene and simultaneously other behavior's models disapeared. Depends of study persons who take dru...
Lekarze specjalizujący się w zakresie chorób wewnętrznych – motywy wyboru specjalizacji, problemy związane z przebiegiem kształcenia oraz plany zawodowe po uzyskaniu specjalizacji
Wstęp. Informacje na temat czynników motywujących do wyboru specjalizacji, sytuacji zawodowej i planów zawodowych oraz problemów w trakcie odbywania specjalizacji przez lekarzy specjalizujących się w zakresie chorób wewn...
Ostra niewydolność nerek u chorego leczonego z powodu szpiczaka plazmocytowego IgG kappa w przebiegu sepsy z cechami mikroangiopatii zakrzepowej
Szpiczak plazmocytowy mimo nowych leków, jest chorobą nieuleczalną o wieloletnim przebiegu. Nowotwory układu chłonnego charakteryzują się głębokimi wtórnymi niedoborami odporności. U chorych z rozpoznaniem szpiczaka plaz...
The influence of Vitamin D deficiency during pregnancy and lactation on the mother and the child
Vitamin D is necessary for maintaining appropriate calcium and phosphate homeostasis in the body (classical function) and for ensuring appropriate functioning of many tissues, organs, cells not related to mineral economy...