Hypoglycemic activity and Phyto-chemical screening on Coccinia grandis leaf and fruit
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Many plant drugs are studied for effecting in the treatment of Diabetes mellitus. In the present study methanolic extract of herb of Coccinia grandis leaf and fruit was evaluated for hypoglycemic effect in Alloxan induced diabetic rats using oral glucose tolerance test. A comparison was made between the actions of methanolic extract Coccinia grandis leaf and fruit and known antidiabetic drug Glibenclamide (5 mg/kg, p.o). The methanolic extract of Coccinia grandis leaf and fruit was administered at doses to normal and diabetic rats. The methanolic extract at 400 mg/kg body weight dose level exhibited significant hypoglycemic activity (P < 0.01 and P < 0.001). Phytochemical screening of methanolic extract revealed the presence of alkaloids, saponins and steroids, flavonoids etc. It is concluded that methanolic extract of herb of Coccinia grandis leaf and fruit posses anti hyperglycemic activity.
Authors and Affiliations
J. V. C. Sharma, P. Swapna, B. Shiva Prasad, A. Ashok, J. L. K Soundarya, G. Mounika 2 ,, B. Parshuram 2
Keywords
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