If the Helicobacter pylori infection may affect ghrelin secretion in children
Journal Title: Postępy Nauk Medycznych - Year 2013, Vol 26, Issue 5
Abstract
<b>Introduction. </b><i>Helicobacter pylori</i> is considered as an etiologic agent of the gastric mucosa diseases. Therefore, it may affect ghrelin secretion, known as “hunger hormone”, by neuroendocrine cells of gastric mucosa.<br><b>Aim. </b>The aim of our study is to determine serum ghrelin concentrations in <i>H. pylori</i> infected and noninfected children.<br><b>Materials and methods.</b> The study involved 84 children, 6-18 years old, living in urban area (Bytom). All patients underwent endoscopy. Biopsy speciments were taken in antrum of the stomach. On the base of the results of urease test and/or positive histological examination (hematoxylin-eosin stained) <i>H. pylori </i>infection was recognized in 33 children (Group I) and in 51 children (Group II) was excluded. Histological lesions of gastric mucosa were diagnosed as: chronic gastritis non active of mild grade or active of mild grade. Serum ghrelin concentration was measured by RIA (Human Radioimmunoassay kit, total ghreline; Millipore).<br><b>Results. </b>There was no significant difference between serum ghrelin concentration in children from Groups I and II. Moreover, in both groups evaluated seperately as well as in the whole group, there was no relationship between the ghrelin levels and the histological estimation of gastric mucosa lesions.<br><b>Conclusions. </b>Our results suggests that <i>H. pylori</i> infection with mild grade of gastric mucosa inflammation does not affect serum ghrelin level in children.
Authors and Affiliations
Anna Obuchowicz, Joanna Kula-Gradzik, Marta Ślimok, Tomasz Wielkoszyński, Jacek Zeckei
Keywords
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