IMMUNOHAEMATOLOGICAL PROFILE OF MATERNAL ANTIBODY-MEDIATED ABO HAEMOLYTIC DISEASE OF FOETUS AND NEWBORN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND The potency of anti-A and anti-B was determined by racial and environmental factors. With respect to ethnic groups, the prevalence and intensity of maternal-newborn ABO incompatibility varied in different populations. The aim of this study is to describe the immunological profile of ABO HDFN. Settings and Design- This was a descriptive study conducted in neonates with ABO HDFN. Research was conducted in Depts. of Transfusion Medicine and Neonatology division of Paediatrics in Govt. Medical College, Trivandrum. MATERIALS AND METHODS Those neonates who fulfilled the inclusion criteria were enrolled in this study. Demographic details, maternal details, bilirubin and haemoglobin levels were recorded. Investigations such as maternal blood grouping and antibody titration were done. In infant’s blood sample direct antiglobulin test, blood grouping and elution was performed. Statistical Analysis- All statistical data were analysed using SPSS software version 16. RESULTS Among mothers of infants with ABO HDFN 25 (22.7%) had a titre of 128, 34 (30.9%) had 256, 35 (31.8%) had 512 and 16 (14.6%) had 1024. Among 110 infants 34 (30.9%) were DAT positive, while the rest 76 (69.1%) were DAT negative. While DAT positive was graded 13 (11.8%) fell in grade 1, 16 (14.6%) in grade 2, 3 (2.7%) in grade 3 and 2 (1.8%) in grade 4 categories. Eluate from 59 (53.6%) of infants with ABO HDFN gave a positive result, while the rest 51 (46.4%) gave a negative result. Out of that 59 (53.6%) elution positive infants, 34 (30.9%) had a positive DAT and 25 (22.7%) had a negative DAT; 51 (46.4%) of infants were negative for both elution and DAT. CONCLUSION Mothers of infants with ABO HDFN had an antibody titre of 128 - 1024. Almost one-third of infants were DAT positive and majority fell in grade 1 or 2. Eluate from half of infants gave a positive result.
Authors and Affiliations
Sajith Vilambil, Meena Dharmadas, Kumari Krishnakumariamma Chakrapani Usha, Shaiji Panthiyil Shahulhameed, Chitra James, Anjaly Padmavilas Sasikala, Soonam John, Vineeth Rajgopal
Keywords
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- EP ID EP265554
- DOI 10.14260/jemds/2017/1110
- Views 93
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