In vitro evaluation of free radical scavenging activity of medicinal plant Polyalthia longifolia (Sonner.) Thw. leaf extract
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
The present study was aimed at investigating the antioxidant activities of the ethanol and chloroform extracts of the leaves of Polyalthia longifolia (Sonner.) Thw. (Annonaceae). The antioxidant activities of the extracts have been evaluated by using ten in vitro assays and were compared to standard antioxidants such as ascorbic acid, a-tocopherol, curcumin, butylated hydroxyl toluene (BHT) and Trolox. Both the extracts showed effective H + donor activity, reducing power, free radical scavenging activity, metal chelating ability, etc. The generation of free radicals, viz., O 2 · - , OH · , H 2 O 2 , NO · and peroxyl radicals, were effectively scavenged by the extracts. The antioxidant property was concentration dependent and increased with increasing amount of the extracts. The total phenolic content, flavonoid content and total antioxidant activity in plant were determined as microgram (µg) pyrocatechol, quercetin and a-tocopherol equivalent/mg, respectively. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds present in the plant. The results obtained in the present study indicate that the leaves of P. longifolia scavenge free radicals and could serve as a potential source of natural antioxidant.
Authors and Affiliations
Andi che t t iar Thi rumalai samy Sivashanmugam and Tapan Kumar Chat t e r j e e*
Keywords
Related Articles
- EP ID EP86672
- DOI -
- Views 107
- Downloads 0
In vitro anti oxidant activity of leaves extracts of Clerodendrum innerme (L.) GAERTN.
Present study is focused to evaluate the anti oxidant potential of the plant Clerodendrum innerme [Verbenaceae]. The plant is called as “Dedonia” in regional language of Satpuda ranges of Maharashtra state,...
Screening and pharmacophore studies of indian plant anticancer compounds database against H-RAS P21 protein inhibitors using molecular docking
Many intracellular proteins are post-translationally modified by the attachment of lipid through the process called farnesylation, which plays an important role in the signal transduction pathway that leads to constant...
Management of hypertension in pregnancy: A review
Hypertension in pregnancy is the most common cause of maternal death, with a risk of approximately 10 deaths / million pregnancies in the UK. Hypertension in pregnancy is also the most common cause of stillbirth and neon...
Purification and sequence identification of alkaline protease produced from Bacillus subtilis KHS-1 (MTCC No. 10110)
The protease from Bacillus subtilis KHS-1 was purified to homogeneity by two step procedure involving ammonium sulfate precipitation and sephadex G-200 gel permeation chromatography. The molecular mass was determined a...
Thevetia peruviana (Pers.) Schum . : A plant with enormous therapeutic potential
An extensive review on the growing requirements, its botany and the medicinal value of this plant has been incorporated. This plant has been known for its diverse range of therapeutic importance in ethno medicine, Ayurv...