Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
Journal Title: Journal of Pharmacy Research - Year 2010, Vol 3, Issue 1
Abstract
The Western Ghats are well known for their rich and unique assemblage of flora and fauna. The present study was conducted to determine antioxidant and anthelmintic potential of two actinomycetes isolates recovered from Western Ghats soils of Agumbe, Karnataka. The isolates were identified as Streptomycetes based on colony appearance, spore arrangement, biochemical and staining characteristics.The antioxidant activity of butanol extract of the culture broth of Streptomyces sp. No 1 and 2 was assessed using DPPH free radical assay and Fe+3 reducing assay. The solvent extracts of the isolates showed a dose dependent antioxidant activity. Anthelmintic activity was determined in adult Indian earthworm model. A marked dose dependent paralysis and death of worms was observed revealing anthelmintic activitiy. Among isolates, Streptomyces sp. No. 2 was found to possess marked antioxidant and anthelmintic efficacy than Streptomyces sp. No. 1. The observed activities of the isolates might be due to active principles present in the solvent extracts. Isolation and purification of the compounds possessing these potentials in the butanol extracts are to be carried.
Authors and Affiliations
T. R. Prashith Kekuda 1*, K. S. Shobha 2, R. Onkarappa 2
Keywords
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