Comparative In vitro screening of a-Amylase and a-Glucosidase enzyme Inhibitory studies in leaves of Annona species
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 12
Abstract
Diabetes is a syndrome of disordered metabolism resulting in abnormally high blood sugar levels (hyperglycemia). The one possibility of lowering postprandial glucose levels is by the inhibition of a-amylase and a-glucosidase enzyme activity. The present study deals with the scientific evaluation of a-Amylase and aGlucosidase enzyme inhibitory potential of different successive extracts of leaves of three A n n o n a species (Annona squamosa-AS, Annona reticulata-AR and, Annona mur i cata-AM). The powdered raw material of three plant leaves was extracted successively with hexane, ethyl acetate and methanol using a soxhlet apparatus and the spent material was then extracted with aqueous methanol followed by water. All the three plants of methanol, and aqueous methanol extracts showed significant reduction in a-amylase and a-glucosidase enzyme activity. But AS and AM plays a vital role in inhibiting a-amylase and a-glucosidase enzyme activity when compared to AR, thereby reducing the blood glucose level and benefiting diabetic patients.
Authors and Affiliations
A . S u n e e l k u m a r *1 , V. Venkatarathanamma 2 , K . S u n e e t a 1 , B . S i v a k uma r i 3
Keywords
Related Articles
- EP ID EP86624
- DOI -
- Views 98
- Downloads 0
Phytochemical profiling, antimicrobial and cytotoxicity studies of methanolic extracts from Ruta graveolens
Aim of study: Ruta graveolens is found to have potential value in traditional medicine its components are of great interest in medicinal chemistry. It contains many active principles that act as antioxidants and possess...
Evaluation of anti-inflammatory activity of the leaf extract of Wrightia tomentosa. Roem & Schult
The methanol: dichloromethane (1:1) extract of the leaves of Wrightia tomentosa (Family: Apocynaceae), a traditional medicine plant was tested for anti-inflammatory activity dextran induced paw edema in rats. The results...
Toxicological Effect of Kerosene Contaminated Diet on the Lipid Profile of Albino Rats
This research work was undertaken to investigate the effect of kerosene on the lipid profile parameters which include total cholesterol (CHO), high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceri...
An overview on silviculture and traditional therapeutic uses of Gmnelina arborea Roxb.
The number of patients seeking alternate and herbal therapy is growing exponentially. Herbal medicines are the synthesis of therapeutic experiences of generations of practicing physicians of indigenous systems of medicin...
Effects of Novel Synthesized Rutaecarpine Analogue on Blood Pressure in the L-NAME Induced Hypertensive Rats
A pharmacological inhibition of nitric oxide synthase (NOS) in rats produces renal vasoconstriction, renal dysfunction, and hypertension. The present study was aimed at investigating whether rutaecarpine analogue amelio...