Effects of Novel Synthesized Rutaecarpine Analogue on Blood Pressure in the L-NAME Induced Hypertensive Rats
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
A pharmacological inhibition of nitric oxide synthase (NOS) in rats produces renal vasoconstriction, renal dysfunction, and hypertension. The present study was aimed at investigating whether rutaecarpine analogue ameliorates N-nitro-l-arginine methyl ester (L-NAME)-induced hypertension. The model rats were assigned to receive L-NAME (40 mg/ (kg day)), L-arginine (100 mg/ (kg day)) by orally and rutaecarpine analogue (3, 10 mg/ (kg day)) by i.p. route with their blood pressure was followed every week. The nitric oxide (NO) concentration in plasma and NO productions in the vascular tissues of the L-NAME-treated group were significantly reduced as compared with those in the control. Rutaecarpine analogue was restored mean arterial blood pressure (MABP) to normal level in the LNAME-treated hypertensive rats. Moreover, was able to preserve NO concentration in plasma. These results suggest that rutaecarpine analogue prevents the increase of MABP in the L-NAME-induced hypertension that may have been caused by enhanced generation of vascular NO.
Authors and Affiliations
Ne e raj B. Munjal 1 , Neeraj S. Vyawahare 1 *, Prasad A. Thakurdesai 2 , Aakanksha A. Dube 1 , Varsha J. Bansode 1
Keywords
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